P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis
文献类型：期刊论文
| 作者 | Geng, JG; Chen, M; Chou, KC |
| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2004 |
| 卷号 | 11期号:16页码:2153-2160 |
| 关键词 | selectin cell adhesion molecule leukocyte platelet endothelial cell cancer cell inflammation thrombosis cancer growth and metastasis |
| 通讯作者 | Geng, JG (reprint author), Univ Minnesota, Sch Med, Vasc Biol Ctr, Minneapolis, MN 55455 USA.,gengx001@umn.edu |
| 英文摘要 | P-selectin (CD62P) is a member of the selectin family of cell adhesion molecules. It is expressed on stimulated endothelial cells and activated platelets and mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. It also mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Using P-selectin knockout mice, the importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, growth and metastasis of cancers has been clearly demonstrated. Here we will summarize the current knowledge and highlight the important progress in the biomedical research of P-selectin biology, providing a suitable target for therapeutic interventions developed through both experimental and bioinformatic approaches. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 关键词[WOS] | ALPHA-GRANULE SECRETION ; PLATELET-ENDOTHELIAL INTERACTIONS ; LIGAND 1 PSGL-1 ; GLYCOPROTEIN LIGAND-1 ; IN-VIVO ; MEMBRANE-PROTEIN ; NEUTROPHIL ADHESION ; VENOUS THROMBOSIS ; MEDIATES ADHESION ; KINETIC-ANALYSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000222533300005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2167]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Geng, JG,Chen, M,Chou, KC. P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis[J]. CURRENT MEDICINAL CHEMISTRY,2004,11(16):2153-2160. |
| APA | Geng, JG,Chen, M,&Chou, KC.(2004).P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis.CURRENT MEDICINAL CHEMISTRY,11(16),2153-2160. |
| MLA | Geng, JG,et al."P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis".CURRENT MEDICINAL CHEMISTRY 11.16(2004):2153-2160. |
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