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Chinese Academy of Sciences Institutional Repositories Grid
Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins

文献类型:期刊论文

作者Barbieri, L; Ciani, M; Girbes, T; Liu, WY; Van Damme, EJM; Peumans, WJ; Stirpe, F
刊名FEBS LETTERS
出版日期2004
卷号563期号:1页码:219-222
关键词ribosome-inactivating protein lectin adenine polynucleotide glycosylase protein synthesis
通讯作者Stirpe, F (reprint author), Univ Bologna, Dipartimento Patol Sperimentale, Via S Giacomo 14, I-40126 Bologna, Italy.,fiorenzo.stirpe@unibo.it
英文摘要Ribosome-inactivating proteins (RIPs) display adenine polynucleotide glycosylase activity on different nucleic acid substrates, which at the ribosomal level is responsible for the arrest of protein synthesis. Some type 2 RIPs, namely ricin and related proteins, are extremely toxic to mammalian cells and animals whilst other type 2 RIPs (non-toxic type 2 RIPs) display three to four logs less toxicity. We studied whether a correlation exists between toxicity on cells and enzymatic activity on nucleic acids. All type 2 RIPs differ in their depurinating activity on the different substrates with differences of up to one to two logs. The toxicity of type 2 RIPs is independent of their enzymatic activity on nucleic acids or on ribosomes. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]SAMBUCUS-NIGRA L ; RICIN-A-CHAIN ; POLYNUCLEOTIDEADENOSINE GLYCOSIDASE ACTIVITY ; EBULUS L ; L BARK ; LECTIN ; PLANT ; RNA ; DNA ; PURIFICATION
收录类别SCI
语种英语
WOS记录号WOS:000220773200041
版本出版稿
源URL[http://202.127.25.143/handle/331003/2197]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Barbieri, L,Ciani, M,Girbes, T,et al. Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins[J]. FEBS LETTERS,2004,563(1):219-222.
APA Barbieri, L.,Ciani, M.,Girbes, T.,Liu, WY.,Van Damme, EJM.,...&Stirpe, F.(2004).Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins.FEBS LETTERS,563(1),219-222.
MLA Barbieri, L,et al."Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins".FEBS LETTERS 563.1(2004):219-222.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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