Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins
文献类型：期刊论文
| 作者 | Barbieri, L; Ciani, M; Girbes, T; Liu, WY; Van Damme, EJM; Peumans, WJ; Stirpe, F |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2004 |
| 卷号 | 563期号:1页码:219-222 |
| 关键词 | ribosome-inactivating protein lectin adenine polynucleotide glycosylase protein synthesis |
| 通讯作者 | Stirpe, F (reprint author), Univ Bologna, Dipartimento Patol Sperimentale, Via S Giacomo 14, I-40126 Bologna, Italy.,fiorenzo.stirpe@unibo.it |
| 英文摘要 | Ribosome-inactivating proteins (RIPs) display adenine polynucleotide glycosylase activity on different nucleic acid substrates, which at the ribosomal level is responsible for the arrest of protein synthesis. Some type 2 RIPs, namely ricin and related proteins, are extremely toxic to mammalian cells and animals whilst other type 2 RIPs (non-toxic type 2 RIPs) display three to four logs less toxicity. We studied whether a correlation exists between toxicity on cells and enzymatic activity on nucleic acids. All type 2 RIPs differ in their depurinating activity on the different substrates with differences of up to one to two logs. The toxicity of type 2 RIPs is independent of their enzymatic activity on nucleic acids or on ribosomes. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | SAMBUCUS-NIGRA L ; RICIN-A-CHAIN ; POLYNUCLEOTIDEADENOSINE GLYCOSIDASE ACTIVITY ; EBULUS L ; L BARK ; LECTIN ; PLANT ; RNA ; DNA ; PURIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000220773200041 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2197]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Barbieri, L,Ciani, M,Girbes, T,et al. Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins[J]. FEBS LETTERS,2004,563(1):219-222. |
| APA | Barbieri, L.,Ciani, M.,Girbes, T.,Liu, WY.,Van Damme, EJM.,...&Stirpe, F.(2004).Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins.FEBS LETTERS,563(1),219-222. |
| MLA | Barbieri, L,et al."Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins".FEBS LETTERS 563.1(2004):219-222. |
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