A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1
文献类型：期刊论文
| 作者 | Wang, LM; Chen, ZY; Zhang, Q; Zhu, W; Ding, DF; Lu, CL; He, C |
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 10期号:1页码:61-72 |
| 关键词 | glial cell line-derived neurotrophic factor receptor alpha 1 RT-PCR mutation expression PC12-cells surival and differentiation |
| 通讯作者 | ,zheyu_chen@hotmail.com ; chenghe@online.sh.cn |
| 英文摘要 | The GFRalpha1 cDNA was amplified by RT-PCR from fetal rat hippocampus. The soluble recombinant GFRalpha1 and its mutants were obtained from an Escherichia coli expression system. The biological activity of soluble GFRalpha1 and its mutants were evaluated in PC12 cells. The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | GDNF FAMILY LIGANDS ; TYROSINE KINASE ; LIPID RAFTS ; C-RET ; NEURONAL SURVIVAL ; NERVOUS-SYSTEM ; GFR-ALPHA-1 ; ACTIVATION ; EXPRESSION ; NEURTURIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000181186600008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2225]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, LM,Chen, ZY,Zhang, Q,et al. A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1[J]. PROTEIN AND PEPTIDE LETTERS,2003,10(1):61-72. |
| APA | Wang, LM.,Chen, ZY.,Zhang, Q.,Zhu, W.,Ding, DF.,...&He, C.(2003).A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1.PROTEIN AND PEPTIDE LETTERS,10(1),61-72. |
| MLA | Wang, LM,et al."A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1".PROTEIN AND PEPTIDE LETTERS 10.1(2003):61-72. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。