Development of CD4(+) T cell lines that suppress an antigen-specific immune response in vivo
文献类型：期刊论文
| 作者 | de Moraes, LV; Sun, B; Rizzo, LV |
| 刊名 | CLINICAL AND EXPERIMENTAL IMMUNOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 131期号:1页码:17-25 |
| 关键词 | regulatory T cells CD4(+)CD25(+) T cells KLH suppression antibody response |
| 通讯作者 | Rizzo, LV (reprint author), Univ Sao Paulo, Clin Immunol Lab, Dept Immunol, Inst Ciencias Biomed, Ave Prof Lineu Prestes 1730, BR-00550890 Sao Paulo, Brazil., |
| 英文摘要 | It has been suggested for many years that the regulation of the immune system for the maintenance of peripheral tolerance may involve regulatory/supressor T cells. In the past few years, several investigators have demonstrated that these cells can be generated in vitro. It has also been shown that they can inhibit the progression of various autoimmune disease models when infused into susceptible mice. We have generated two murine T cell lines in the presence of KLH-specific T cell clones from BALB/c or DBA2 mice. The lines are characterized by a low proliferative response to mitogens, the capacity to secrete high amounts of IL-10 and TGF-beta, and small amounts of IFN-gamma. Interestingly, these cells are unable to produce IL-2, IL-4 or IL-5. The study of the surface phenotype of both lines revealed CD4(+) , CD25(high), CD44(low) and CTLA-4(-) cells. When injected intravenously in (CBy.D2) F1 mice, these cells were able to inhibit 50-100% of the TNP-specific antibody production, when the hapten was coupled to KLH. In the present study we offer another evidence for the existence of regulatory T cells in the T lymphocyte repertoire, suggesting that they can also regulate immune responses to foreign antigens. Furthermore, we demonstrate an alternative pathway to generate these cells different from approaches used thus far. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | IMMUNOLOGICAL SELF-TOLERANCE ; SPONTANEOUS AUTOIMMUNE ENCEPHALOMYELITIS ; LYMPHOCYTE-ASSOCIATED ANTIGEN-4 ; TRANSGENIC MICE ; TRANSPLANTATION TOLERANCE ; CYTOKINE PRODUCTION ; PERIPHERAL-BLOOD ; TGF-BETA ; IN-VIVO ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000180250500003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2235]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | de Moraes, LV,Sun, B,Rizzo, LV. Development of CD4(+) T cell lines that suppress an antigen-specific immune response in vivo[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2003,131(1):17-25. |
| APA | de Moraes, LV,Sun, B,&Rizzo, LV.(2003).Development of CD4(+) T cell lines that suppress an antigen-specific immune response in vivo.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,131(1),17-25. |
| MLA | de Moraes, LV,et al."Development of CD4(+) T cell lines that suppress an antigen-specific immune response in vivo".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 131.1(2003):17-25. |
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