热门
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of cdc42
文献类型：期刊论文
| 作者 | Li, Z; Hannigan, M; Mo, ZC; Liu, B; Lu, W; Wu, Y; Smrcka, AV; Wu, GQ; Li, L; Liu, MY |
| 刊名 | CELL
 |
| 出版日期 | 2003 |
| 卷号 | 114期号:2页码:215-227 |
| 通讯作者 | Wu, DQ (reprint author), Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA., |
| 英文摘要 | Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving Gbetagamma, PAK-associated guanine nucleotide exchange factor (PIXalpha), Cdc42, and p21-activated kinase (PAK) 1. This pathway is utilized by chemoattractants to regulate directional sensing and directional migration of myeloid cells. Our results suggest that Gbetagamma binds PAKI and, via PAK-associated PIXa, activates Cdc42, which in turn activates PAK1. Thus, in this pathway, PAKII is not only an effector for Cdc42, but it also functions as a scaffold protein required for Cdc42 activation. This Gbetagamma-PAK1/PIXalpha/Cdc42 pathway is essential for the localization of F-actin formation to the leading edge, the exclusion of PTEN from the leading edge, directional sensing, and the persistent directional migration of chemotactic leukocytes. Although ligand-induced production Of PIP3 is not required for activation of this pathway, PIP3 appears to localize the activation of Cdc42 by the pathway. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | NUCLEOTIDE EXCHANGE FACTOR ; ADAPTER PROTEIN NCK ; P21-ACTIVATED KINASES ; SIGNALING PATHWAYS ; MEMBRANE LOCALIZATION ; HUMAN NEUTROPHILS ; MAMMALIAN-CELLS ; LIPID PRODUCTS ; RHO-GTPASES ; CHEMOTAXIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184378700011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2247]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, Z,Hannigan, M,Mo, ZC,et al. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of cdc42[J]. CELL,2003,114(2):215-227. |
| APA | Li, Z.,Hannigan, M.,Mo, ZC.,Liu, B.,Lu, W.,...&Wu, DQ.(2003).Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of cdc42.CELL,114(2),215-227. |
| MLA | Li, Z,et al."Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of cdc42".CELL 114.2(2003):215-227. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。