The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma
文献类型：期刊论文
| 作者 | Zhi, HY; Zhang, J; Hu, GX; Lu, JY; Wang, XQ; Zhou, CN; Wu, M; Liu, ZH |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2003 |
| 卷号 | 106期号:3页码:327-333 |
| 关键词 | cDNA microarray esophageal squamous cell carcinoma arachidonic acid metabolism pathway gene expression |
| 通讯作者 | Liu, ZH (reprint author), Chinese Acad Med Sci, Inst Canc, Natl Lab Mol Oncol, Beijing 100021, Peoples R China., |
| 英文摘要 | Esophageal squamous cell carcinoma (ESCC) is I of the most common cancers worldwide. In our study, cDNA microarray comprising 14,803 genes was employed to identify gene-specific expression profile in 6 paired samples of ESCC. Nine genes identified were commonly upregulated and 36 downregulated in tumors, as compared to normal esophageal squamous epithelia. Among these genes, we found that 9 of the altered expression genes were related to arachidonic acid (AA) metabolism, such as annexin-1, annexin-11, S100A8, S100A10, S100P, glutathione peroxidase-3, phosphatidylcholine transfer protein, aldo-keto reductase family I and cyclooxygenase-2 (COX-2). To gain insights into the regulation of the AA metabolism pathway involved in the carcinogenesis of ESCC, we investigated the expression of 8 genes related to the AA metabolism by semiquantitative reverse transcript (RT)-PCR and/or Western blot and immunohistochemistry. These genes include annexin-1, annexin-11, COX-2, cyclooxygenase-1 (COX-1) and cytosolic phospholipase A(2) (cPLA(2)), 5-tipoxygenose (5-LOX), 5-lipoxygenase activating protein (FLAP) and 12-lipoxygenase (12-LOX) (not included in the array data). The expression level of annexin-1, annexin-11 was downregulated in esophageal cancer, whereas cPLA2. FLAP, COX-2, 5-LOX and 12-LOX were upregulated. These data suggested that AA metabolism pathway and its altered expression may contribute to esophageal squamous cell carcinogenesis. (C) 2003 Wiley-Liss, Inc. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | CALCIUM-BINDING PROTEINS ; CYTOSOLIC PHOSPHOLIPASE A(2) ; HIGH-INCIDENCE AREA ; ANNEXIN-I ; CYCLOOXYGENASE-2 EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; PROGNOSTIC-SIGNIFICANCE ; CORNIFIED ENVELOPE ; INDUCED APOPTOSIS ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184277500005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2262]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhi, HY,Zhang, J,Hu, GX,et al. The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CANCER,2003,106(3):327-333. |
| APA | Zhi, HY.,Zhang, J.,Hu, GX.,Lu, JY.,Wang, XQ.,...&Liu, ZH.(2003).The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma.INTERNATIONAL JOURNAL OF CANCER,106(3),327-333. |
| MLA | Zhi, HY,et al."The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma".INTERNATIONAL JOURNAL OF CANCER 106.3(2003):327-333. |
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