Identification of Gal-alpha-1,3-Gal peptide mimetic by phage display
文献类型：期刊论文
| 作者 | Zhang, H; Zhan, JB; Xu, LH; Yan, ZK; Wang, KY |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2003 |
| 卷号 | 30期号:3页码:461-465 |
| 关键词 | phage display hyperacute rejection (HAR) pig RBC agglutination assay GS-I-B4 |
| 通讯作者 | , |
| 英文摘要 | The obstacle for pig-to-human transplantation is hyperacute rejection (HAR) triggered by the interaction between human natural antibodies and the antigenic epitope Gal-alpha-1, 3 -Gal. The alpha-Gal structure is considered to be the major xenoantigenic epitopes present on porcine tissues. A phage-displayed peptide library is used to identify a 17-amino-acid peptide CCWLLRQPVPFVRSIRS that binds to the mAb anti-B (anti-B monoclonal antibody which binds the carbohydrate Gal alpha-1, 3 Gal). The melibiose competes with the binding of mAB anti-B to the peptide, suggesting that they may bind the same site. Using a pig RBC agglutination assay, it is shown that this peptide can inhibit the agglutination of pig RBCs by human serum or GS-I-B4. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | LIBRARY |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000183733500025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2266]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, H,Zhan, JB,Xu, LH,et al. Identification of Gal-alpha-1,3-Gal peptide mimetic by phage display[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(3):461-465. |
| APA | Zhang, H,Zhan, JB,Xu, LH,Yan, ZK,&Wang, KY.(2003).Identification of Gal-alpha-1,3-Gal peptide mimetic by phage display.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(3),461-465. |
| MLA | Zhang, H,et al."Identification of Gal-alpha-1,3-Gal peptide mimetic by phage display".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.3(2003):461-465. |
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