Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I
文献类型：期刊论文
| 作者 | Hu, JH; Yang, N; Ma, YH; Zhou, XG; Zhang, XY; Jiang, J; Mei, ZT; Fei, JA; Guo, LH |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 74期号:4页码:614-621 |
| 关键词 | GABA transporter morphine dependence transgenic mouse |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Morphine addiction has been shown to result from neural adaptations produced by repeated drug exposure, but the mechanism is still unclear. In the present study, we found that gamma-aminobutyric acid (GABA) uptake was increased in mouse brain 120 min after, but not 20 min after, morphine (10 mg/kg, s.c.) injection. We generated GABA transporter I (GAT1)-overexpressing mice to investigate whether the GABAergic system and GABA transporter are involved in morphine-induced reward effects and withdrawal symptoms. Our results revealed that the rewarding effects induced by morphine were significantly decreased in GAT1-overexpressing mice as measured by the conditioned place preference (CPP) paradigm. Moreover, both somatic and vegetative signs of naloxone-induced morphine withdrawal symptoms were substantially reduced in GAT1-overexpressing mice. In addition, the decreased morphine rewarding in transgenic mice could be recovered when mice were coinjected with NO-711 (a GAT1 selective inhibitor) in the CPP paradigm. These findings suggest that the GABAergic system plays an important role in morphine addiction and point to the possibility of developing drugs that target GAT1 and extend the clinical application of opiates. (C) 2003 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | TRANSGENIC MICE ; NUCLEUS-ACCUMBENS ; GABA TRANSPORTER ; SYNAPTIC-TRANSMISSION ; INDUCED ANALGESIA ; MOUSE-BRAIN ; RAT-BRAIN ; ADDICTION ; DOPAMINE ; RELEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000186348900016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2273]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, JH,Yang, N,Ma, YH,et al. Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2003,74(4):614-621. |
| APA | Hu, JH.,Yang, N.,Ma, YH.,Zhou, XG.,Zhang, XY.,...&Guo, LH.(2003).Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I.JOURNAL OF NEUROSCIENCE RESEARCH,74(4),614-621. |
| MLA | Hu, JH,et al."Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I".JOURNAL OF NEUROSCIENCE RESEARCH 74.4(2003):614-621. |
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