Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice
文献类型：期刊论文
| 作者 | Hu, JH; Yang, N; Ma, YH; Zhou, XG; Jiang, J; Duan, SH; Mei, ZT; Fei, J; Guo, LH |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 73期号:4页码:565-572 |
| 关键词 | GABA uptake GABA transporter overexpressing pain antinociception |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | The present study focused on the involvement of gamma-aminobutyric acid transporter I (GAT1) in pain. We found that GABA uptake was increased in mouse spinal cord at 20 min and 120 min after formalin injection and in mouse brain at 120 min, but not 20 min, after formalin injection. In addition, the antinociceptive effects of GAT1-selective inhibitors were examined using assays of thermal (tail-flick) and chemical (formalin and acetic acid) nociception in C57BU6J mice. The GAT1-selective inhibitors, ethyl nipecotate and NO-711, exhibited significant antinociceptive effects in these nociceptive assays. To study further the effects of GAT1 on pain, we used two kinds of GAT1-overexpressing transgenic mice (under the control of a CMV promoter or a NSE promoter) to examine the nociceptive responses in these mice. In the thermal, formalin, and acetic acid assays, both kinds of transgenic mice displayed significant hyperalgesia after nociceptive stimuli. In addition, the V opioid receptor antagonist naloxone had no influence on nociceptive responses in wild-type and transgenic mice. The results indicate that GAT1 is involved in the regulation of pain processes, and point to the possibility of developing analgesic drugs that target GAT1 other than opioid receptors. (C) 2003 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | RAT SPINAL-CORD ; FACIAL CARRAGEENAN INJECTIONS ; GABA TRANSPORTER ; AFFERENT TERMINALS ; TRANSGENIC MICE ; MOUSE-BRAIN ; EXPRESSION ; GAT-1 ; OVEREXPRESSION ; LOCALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184521000015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2274]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, JH,Yang, N,Ma, YH,et al. Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2003,73(4):565-572. |
| APA | Hu, JH.,Yang, N.,Ma, YH.,Zhou, XG.,Jiang, J.,...&Guo, LH.(2003).Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice.JOURNAL OF NEUROSCIENCE RESEARCH,73(4),565-572. |
| MLA | Hu, JH,et al."Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice".JOURNAL OF NEUROSCIENCE RESEARCH 73.4(2003):565-572. |
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