Deducing functional epitopes for GDNF proteins and its specific GFR alpha co-receptors using phylogenetic approach
文献类型：期刊论文
| 作者 | Zhang, Q; Wang, LM; Chen, ZY; Ding, DF |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2003 |
| 卷号 | 35期号:4页码:331-337 |
| 关键词 | glial cell line-derived neurotrophic factor (GDNF) family GFR alpha family TGF-beta super family functional epitope evolutionary trace |
| 通讯作者 | ,dingdafu@server.shcnc.ac.cn |
| 英文摘要 | Glial cell line-derived neurotrophic factor (GDNF) has received much attention as potential therapeutic agent for the treatment of neurodegenerative diseases. It Will be very important to discover the molecular mechanism of this factor and its specific GFRalpha co-receptor. Based on the principle of molecular evolution that site-specific functional importance is relevant to the pressure it undergoes under natural selection, evolutionary trace method was used to identify the functional epitopes in GDNF and GFRalpha families. Some trace residues had been proved to be important in ligand-receptor binding, especially in rat GFRalpha1, Where alanine scanning mutagenesis confirmed that sites N-152 N-153, R-259, (SNS318)-N-316-S-317 and Q(247) (DS249)-S-248 were critical for GFRalpha1 binding to GDNF or Ret and thus affected the formation of GDNF-GFRalpha1-Ret complex. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | NEUROTROPHIC FACTOR ; BINDING ; IDENTIFICATION ; INFORMATION ; COMPLEX ; FAMILY ; LIGAND ; BETA |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000182522800004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2282]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Q,Wang, LM,Chen, ZY,et al. Deducing functional epitopes for GDNF proteins and its specific GFR alpha co-receptors using phylogenetic approach[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(4):331-337. |
| APA | Zhang, Q,Wang, LM,Chen, ZY,&Ding, DF.(2003).Deducing functional epitopes for GDNF proteins and its specific GFR alpha co-receptors using phylogenetic approach.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(4),331-337. |
| MLA | Zhang, Q,et al."Deducing functional epitopes for GDNF proteins and its specific GFR alpha co-receptors using phylogenetic approach".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.4(2003):331-337. |
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