Regulation of angiogenic signaling pathway by two human aminoacyl-tRNA synthetases
文献类型：期刊论文
| 作者 | Zhao, MW; Wang, ED |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2003 |
| 卷号 | 30期号:5页码:689-693 |
| 关键词 | aminoacyl-tRNA synthetase tyrosyl-tRNA synthetase tryptophanyl-tRNA synthetase cytokine signaling pathway angiogenesis chemokine |
| 通讯作者 | Wang, ED (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | Aminoacyl-tRNA synthetases are key enzymes in protein biosynthesis that catalyze aminoacylation of their cognate tRNA. During their long evolution, these ancient enzymes incorporated new domains by insertions or fusions to the class-defining catalytic core to attend more functions. Recently, fragments of the closely related human tyrosyl- and tryptophanyl-tRNA synthetases were discovered to be active in angiogenesis signaling pathway. One synthetase fragment has proangiogenic activity, while the other is antiangiogenic. These two tRNA synthetases link protein synthesis to a major cell-signaling pathway in the given mammalian cells. The results with animals suggest that therapeutic applications for many human diseases such as neovascular eye disease and tumor are possible with these tRNA synthetases. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ACTIVATING POLYPEPTIDE-II ; CYTOKINE ; MYOSITIS ; AUTOANTIBODIES ; IDENTIFICATION ; EXPRESSION ; RECEPTORS ; FRAGMENT ; CELLS |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000185930900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2295]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, MW,Wang, ED. Regulation of angiogenic signaling pathway by two human aminoacyl-tRNA synthetases[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(5):689-693. |
| APA | Zhao, MW,&Wang, ED.(2003).Regulation of angiogenic signaling pathway by two human aminoacyl-tRNA synthetases.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(5),689-693. |
| MLA | Zhao, MW,et al."Regulation of angiogenic signaling pathway by two human aminoacyl-tRNA synthetases".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.5(2003):689-693. |
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