The role of tyrosine residues in the RNA N-glycosidase activity of cinnamomin A-chain
文献类型：期刊论文
| 作者 | Xu, H; Liu, WY |
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 10期号:5页码:503-509 |
| 关键词 | chemical modification cinnamomin A-chain ribosome-inactivating protein RNA N-glycosidase tryptophan residue tyrosine residue |
| 通讯作者 | Liu, WY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Cinnamomin is a type 11 ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosiclase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed that tyrosine residues are involved in the active site of CTA and they are crucial in recognition and binding of ribosomal RNA. Tryptophan residues of CTA are also studied by NBS modification. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | RIBOSOME-INACTIVATING PROTEINS ; CAMPHOR TREE ; B-CHAIN ; II RIP ; RICIN ; MECHANISM ; SEEDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185568700011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2297]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, H,Liu, WY. The role of tyrosine residues in the RNA N-glycosidase activity of cinnamomin A-chain[J]. PROTEIN AND PEPTIDE LETTERS,2003,10(5):503-509. |
| APA | Xu, H,&Liu, WY.(2003).The role of tyrosine residues in the RNA N-glycosidase activity of cinnamomin A-chain.PROTEIN AND PEPTIDE LETTERS,10(5),503-509. |
| MLA | Xu, H,et al."The role of tyrosine residues in the RNA N-glycosidase activity of cinnamomin A-chain".PROTEIN AND PEPTIDE LETTERS 10.5(2003):503-509. |
入库方式： OAI收割
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