TGF-beta 1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production
文献类型：期刊论文
| 作者 | Chen, HH; Zhao, S; Song, JG |
| 刊名 | CELL DEATH AND DIFFERENTIATION
 |
| 出版日期 | 2003 |
| 卷号 | 10期号:5页码:516-527 |
| 关键词 | apoptosis TGF-beta 1 ceramide MAPK signaling |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Serum deprivation induces apoptosis in NIH3T3 cells, which is associated with increased intracellular ceramide generation and with the activation of p38 mitogen-activated protein (MAP) kinase. Treatment of cells with transforming growth factor-beta1 (TGF-beta1) activated the extracellular signal regulated kinases 1 and 2 (ERK1/ERK2), inhibited the serum deprivation-induced p38 activation and the increase in intracellular ceramide formation, leading to the stimulation of cell proliferation and the suppression of apoptosis. Inhibition of p38 MAP kinase by SB203580 significantly reduced the serum-deprivation-induced apoptosis. Overexpression of p38 increased the cell apoptosis and reduced the antiapoptotic effect of TGF-beta1. Inhibition of ERK1/ERK2 by PD98059 completely inhibited the TGF-beta1-stimulated proliferation and partially inhibited the antiapoptotic effects of TGF-beta1. Neither SB203580 nor PD98059 has obvious effect on TGF-beta1-mediated inhibition of the increased ceramide generation. Serum-deprivation-induced apoptosis in NIH3T3 cells can also be blocked by broad-spectrum caspase inhibitor. TGF-beta1 treatment has an inhibitory effect on caspase activities. Our results indicate that ceramide, p38, and ERK1/ERK2 play critical but differential roles in cell proliferation and stress-induced apoptosis. TGF-beta1 suppresses the serum-deprivation-induced apoptosis via its distinct effects on complex signaling events involving the activation of ERK1/ERK2 and the inhibition of p38 activation and increased ceramide generation. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; FACTOR BETA-1-INDUCED APOPTOSIS ; TGF-BETA ; ADIPOCYTE DIFFERENTIATION ; TRANSFORMING GROWTH-FACTOR-BETA-1 ; CELL DIFFERENTIATION ; SIGNAL-TRANSDUCTION ; EPITHELIAL-CELLS ; KAPPA-B ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000183022700006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2305]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, HH,Zhao, S,Song, JG. TGF-beta 1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production[J]. CELL DEATH AND DIFFERENTIATION,2003,10(5):516-527. |
| APA | Chen, HH,Zhao, S,&Song, JG.(2003).TGF-beta 1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production.CELL DEATH AND DIFFERENTIATION,10(5),516-527. |
| MLA | Chen, HH,et al."TGF-beta 1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production".CELL DEATH AND DIFFERENTIATION 10.5(2003):516-527. |
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