LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication
文献类型：期刊论文
| 作者 | Cai, YN; Zhou, Q; Kong, YY; Li, M; Viollet, B; Xie, YH; Wang, Y |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 13期号:6页码:451-458 |
| 关键词 | LRH-1/hB1F HNF1 HBV ENII synergism |
| 通讯作者 | Wang, Y (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,yhxie@sibs.ac.cn ; wangy@sibs.ac.cn |
| 英文摘要 | Enhancer II (ENII) is one of the critical cis-elements in the Hepatitis B Virus (HBV) genome for the hepatic viral gene transcription and DNA replication. The liver-specific activity of ENII is regulated by multiple liver-enriched transcription factors, including LRH-1/hB1F, HNF1, HNF3beta, HNF4 and C/EBP. Knowledge on the interplay of these important factors is still limited. In this study, we demonstrate a functional synergism between the orphan nuclear receptor LRH-1/hB1F and the homeoprotein HNF1 in up-regulating the liver-specific activity of ENII. This synergism is sufficient for initiating the viral gene transcription and DNA replication in non-hepatic cells. We have defined the activation domains in hB1F and HNF1 that contribute to the synergism. We further show that hB1F and HNF1 can interact directly in vitro and have mapped the domains required for this interaction. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | NUCLEAR FACTOR-I ; CORE PROMOTER ; BINDING DOMAIN ; ENHANCER-II ; RECEPTOR ; ENII ; TRANSACTIVATION ; EXPRESSION ; ELEMENTS ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000187857000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2310]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cai, YN,Zhou, Q,Kong, YY,et al. LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication[J]. CELL RESEARCH,2003,13(6):451-458. |
| APA | Cai, YN.,Zhou, Q.,Kong, YY.,Li, M.,Viollet, B.,...&Wang, Y.(2003).LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.CELL RESEARCH,13(6),451-458. |
| MLA | Cai, YN,et al."LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication".CELL RESEARCH 13.6(2003):451-458. |
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