An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy
文献类型：期刊论文
| 作者 | Zhang, ZL; Zou, WG; Luo, CX; Li, BH; Wang, JH; Sun, LY; Qian, QJ; Liu, XY |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 13期号:6页码:481-489 |
| 关键词 | ZD55-gene oncolytic adenovirus E1B 55-kD gene cancer Gene-ViroTherapy |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Biotechnol Lab, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of E1B55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | SELECTIVELY-REPLICATING ADENOVIRUS ; COMPETENT ADENOVIRUS ; THERAPEUTIC VIRUSES ; GENE DELIVERY ; TUMOR-CELLS ; NECK-CANCER ; E3 REGION ; ONYX-015 ; CARCINOMA ; E1B-55K |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000187857000007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2311]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, ZL,Zou, WG,Luo, CX,et al. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy[J]. CELL RESEARCH,2003,13(6):481-489. |
| APA | Zhang, ZL.,Zou, WG.,Luo, CX.,Li, BH.,Wang, JH.,...&Liu, XY.(2003).An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy.CELL RESEARCH,13(6),481-489. |
| MLA | Zhang, ZL,et al."An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy".CELL RESEARCH 13.6(2003):481-489. |
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