Cinnamomin: a multifunctional type II ribosome-inactivating protein
文献类型：期刊论文
| 作者 | He, WJ; Liu, WY |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 35期号:7页码:1021-1027 |
| 关键词 | cinnamomin deadenylation ribosome-inactivating protein (RIP) RNA N-glycosidase |
| 通讯作者 | Liu, WY (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Plant ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can irreversibly inactivate ribosomes by specifically removing the conserved adenine base from the "Sarcin/Ricin domain" of the 28S RNA in ribosome. Cinnamomin is a novel type II RIP isolated in our laboratory from the mature seeds of camphor tree. Besides site-specific deadenylation of the A4324 in the Sarcin/Ricin domain of rat ribosome, this protein could also release the adenine base from DNA molecules at multiple sites and from AMP, ADP, dAMP and adenosine. Furthermore, cinnamomin displays cytotoxicity to carcinoma cells and insect larvae by modifying their ribosomal RNA. These functions possessed by cinnamomin shed a new light on the possible application of cinnamomin in the field of immunotoxin design and transgenic reagents. In this review, we introduce the major recent results on cinnamomin obtained in our laboratory, including purification of this protein, characterization of its enzymatic mechanism, structure and function, gene pattern, physiological role and its biological implications in cytotoxicity. (C) 2003 Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | N-GLYCOSIDASE ACTIVITY ; EUKARYOTIC RIBOSOMES ; CAMPHOR TREE ; MAGNETIC-RESONANCE ; B-CHAIN ; A-CHAIN ; SEEDS ; RNA ; CLEAVAGE ; PURIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000182765100004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2326]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | He, WJ,Liu, WY. Cinnamomin: a multifunctional type II ribosome-inactivating protein[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2003,35(7):1021-1027. |
| APA | He, WJ,&Liu, WY.(2003).Cinnamomin: a multifunctional type II ribosome-inactivating protein.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,35(7),1021-1027. |
| MLA | He, WJ,et al."Cinnamomin: a multifunctional type II ribosome-inactivating protein".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 35.7(2003):1021-1027. |
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