Estimating coarse gene networks from yeast gene expression time series
文献类型：期刊论文
| 作者 | Xu, XJ; Wang, LS; Ding, DF |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2003 |
| 卷号 | 35期号:8页码:707-716 |
| 关键词 | gene regulatory network genome time serial expression cell cycle environmental stress |
| 通讯作者 | Ding, DF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China.,dingdafu@server.shcnc.ac.cn |
| 英文摘要 | Gene networks is the collection of gene-gene regulatory relations at the expression level. In this study,. a combined approach of the linear transcriptional modeling, identification of promoter elements and gene co-expression clustering is developed to decipher yeast gene networks from expression time series. The cell must reorganize the genomic expression to programs required for growth and survival in each environment. The expression of many genes is regulated by environmental stress. The products of many genes that induced in the environmental stress are involved in metabolism of carbohydrates, structural repairs and even sporulation. Interestingly, it is identified that transcription factors Mcm1 and Dal82 matched their binding sites TT-CC---T--GGAAA and TGAAAAWTTT in cell cycle progression and environmental stress response, respectively. These conclusions agree with the known observations. The results indicate that the approach may be useful for modeling gene networks from microarray data. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | TRANSCRIPTIONAL REGULATORY NETWORKS ; SACCHAROMYCES-CEREVISIAE ; CELL-CYCLE ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000184988600005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2328]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, XJ,Wang, LS,Ding, DF. Estimating coarse gene networks from yeast gene expression time series[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(8):707-716. |
| APA | Xu, XJ,Wang, LS,&Ding, DF.(2003).Estimating coarse gene networks from yeast gene expression time series.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(8),707-716. |
| MLA | Xu, XJ,et al."Estimating coarse gene networks from yeast gene expression time series".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.8(2003):707-716. |
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