Overexpression of STAT3 in COS7 cells causes prominent morphological changes
文献类型：期刊论文
| 作者 | Yan, Y; Xia, CH; Cao, XM; Jing, NH |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2003 |
| 卷号 | 35期号:8页码:717-722 |
| 关键词 | COS7 cell Stat3 overexpression cell morphology reporter gene |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Shanghai 200031, Peoples R China., |
| 英文摘要 | Signal transducer and activator of transcription 3 (STAT3) plays a central role in mediating signals related to cell growth, differentiation, survival and movement. In this report, the results of immunocytochemistry and Western blot analysis showed that the active form of Stat3 protein existed in COS7 cells. The endogenous Stat3 protein could also induce the expression of m67-sequence-directed reporter genes. The transient transfection of StaB cDNA into COS7 cells increased Stat3 protein level and the expression of the reporter gene. The overexpression of Stat3 protein in COS7 cells caused prominent cell morphological changes. These cells had a much larger cell body, extended long processes with branches, lamellipodia and filopodia. These results suggest that Stat3 protein may, play important roles in cell adhension, migration and cytoskeleton reorganization. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SIGNALING PATHWAY ; GROWTH ; GENE ; ACTIVATION ; FAMILY ; MOUSE ; ROLES ; DIFFERENTIATION ; EXPRESSION ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000184988600006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2329]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yan, Y,Xia, CH,Cao, XM,et al. Overexpression of STAT3 in COS7 cells causes prominent morphological changes[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(8):717-722. |
| APA | Yan, Y,Xia, CH,Cao, XM,&Jing, NH.(2003).Overexpression of STAT3 in COS7 cells causes prominent morphological changes.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(8),717-722. |
| MLA | Yan, Y,et al."Overexpression of STAT3 in COS7 cells causes prominent morphological changes".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.8(2003):717-722. |
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