N-desulfated heparin improves concanavalin A-induced liver injury partly through inhibiting T lymphocyte adhesion
文献类型：期刊论文
| 作者 | Yuan, L; Geng, JG; Xu, Q |
| 刊名 | INFLAMMATION RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 52期号:9页码:383-389 |
| 关键词 | N-desulfated heparin Con A liver injury lymphocytes adhesion |
| 通讯作者 | Xu, Q (reprint author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, 22 Han Kou Rd, Nanjing 210093, Peoples R China., |
| 英文摘要 | Objective and Design: To examine the effect of N-desulfated heparin on Concanavalin A (Con A)-induced liver injury and its mechanisms of action. Materials and methods: Liver injury was induced in mice by Con A. The in vitro assays for examining the adhesions of spleen T lymphocytes and Jurkat cells to extracellular matrix (ECM) were also performed. Results: N-desulfated heparin significantly inhibited the elevation in alanine transaminase, aspartate transaminase and lactic dehydrogenase activities in serum, and recovered the superoxide dismutase activity in the liver tissue of mice with liver injury. In liver histological examination, the inflammatory infiltration, hepatocyte degeneration and Kupffer cell hyperplasia were remarkably improved by N-desulfated heparin. Multiple administrations of the heparin derivative for one day showed a more potent prevention of the liver injury than did single dosing for three days. N-desulfated heparin significantly inhibited the adhesion of spleen cells and purified T lymphocytes isolated from the liver injured mice to either type I collagen or fibronectin but not to laminin. The heparin derivative also showed a similar inhibition of the adhesion of spleen cells from normal mice, stimulated in vitro with Con A, whereas it did not affect their proliferation. Moreover, the adhesion of human leukemia Jurkat cells to collagen I was inhibited by N-desulfated heparin. Conclusion: N-desulfated heparin may improve immunological liver injury partly via reducing the functions, such as the adhesion to ECM, of T lymphocytes. |
| 学科主题 | Cell Biology; Immunology |
| 类目[WOS] | Cell Biology ; Immunology |
| 关键词[WOS] | NON-ANTICOAGULANT HEPARIN ; EXTRACELLULAR-MATRIX ; REPERFUSION INJURY ; IN-VIVO ; CELL ADHESION ; L-SELECTIN ; SULFATE ; MICE ; GLYCOSAMINOGLYCANS ; DYSFUNCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185481400006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2348]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yuan, L,Geng, JG,Xu, Q. N-desulfated heparin improves concanavalin A-induced liver injury partly through inhibiting T lymphocyte adhesion[J]. INFLAMMATION RESEARCH,2003,52(9):383-389. |
| APA | Yuan, L,Geng, JG,&Xu, Q.(2003).N-desulfated heparin improves concanavalin A-induced liver injury partly through inhibiting T lymphocyte adhesion.INFLAMMATION RESEARCH,52(9),383-389. |
| MLA | Yuan, L,et al."N-desulfated heparin improves concanavalin A-induced liver injury partly through inhibiting T lymphocyte adhesion".INFLAMMATION RESEARCH 52.9(2003):383-389. |
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