Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1
文献类型：期刊论文
| 作者 | Xu, PL; Kong, YY; Xie, YH; Wang, YA |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2003 |
| 卷号 | 35期号:10页码:897-903 |
| 关键词 | hB1F/hLRH-1 orphan nuclear receptor repression SMRT HBV enhancer II/core promoter |
| 通讯作者 | Xie, YH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | The orphan nuclear receptor hB1F (also known as NR5A2, LRH-1, FTF or CPF) plays important roles in regulating the expression of several cellular and viral genes actively involved in a wide range of biological processes such as the bile acid biosynthesis, liver specific gene regulatory network and hepatitis B virus replication. The activity of nuclear receptors is regulated by multiple mechanisms, including coactivation and corepression. In this study, it was found that the silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT) specifically represses the transcriptional activity of hB1F, on either GAIN dependent reporter system or the hB1F-responsive HBV enhancer II/core promoter. The repression imposed by SMRT is observed in different cell lines. Interestingly, hB1F couldn't interact with SMRT directly, as demonstrated by mammalian two-hybrid analysis or GST pull-down assay. Taken together, it can be concluded for the first time that the transcriptional activity of hB1F is regulated specifically by the corepressor SMRT via an indirect mechanism. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | HEPATITIS-B VIRUS ; HORMONE RECEPTORS ; GENE-EXPRESSION ; CO-REPRESSOR ; N-COR ; HOMOLOG-1 ; COACTIVATOR ; COMPLEXES ; FACTOR-1 ; FTZ-F1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000186075100005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2352]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, PL,Kong, YY,Xie, YH,et al. Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(10):897-903. |
| APA | Xu, PL,Kong, YY,Xie, YH,&Wang, YA.(2003).Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(10),897-903. |
| MLA | Xu, PL,et al."Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.10(2003):897-903. |
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