Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction
文献类型：期刊论文
| 作者 | Huo, HR; Guo, XM; Hong, SY; Jiang, MR; Liu, XY; Liao, K |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2003 |
| 卷号 | 278期号:13页码:11561-11569 |
| 通讯作者 | Liao, K (reprint author), Shanghai Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Lipid rafts/caveolae are found to be essential for insulin-like growth factor (IGF)-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction. In 3T3-L1 cells, IGF-1 receptor is located in lipid rafts/caveolae of the plasma membrane and can directly interact with caveolin-1, the major protein component in caveolae. Disruption of lipid rafts/caveolae by depleting cellular cholesterol with cholesterol-binding reagent, beta-methylcyclodextrin or filipin, blocks the IGF-1 receptor signaling in 3T3-L1 preadipocyte. Both hormonal induced adipocyte differentiation and mitotic clonal expansion are inhibited by lipid rafts/caveolae disruption. However, a nonspecific lipid binding reagent, xylazine, does not affect adipocyte differentiation or mitotic clonal expansion. Further studies indicate that lipid rafts/caveolae are required only for IGF-1 receptor downstream signaling and not the activation of receptor itself by ligand. Thus, our results suggest that localization in lipid rafts/caveolae and association with caveolin enable IGF-1 receptor to have a close contact with downstream signal molecules recruited into lipid rafts/caveolae and transmit the signal through these signal molecule complexes. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; FACTOR-I RECEPTOR ; TYROSINE PHOSPHORYLATION ; CAVEOLAE MEMBRANE ; ADIPOCYTE DIFFERENTIATION ; CHOLESTEROL DEPLETION ; GLUT4 TRANSLOCATION ; PLASMA-MEMBRANE ; MDCK CELLS ; C-CRK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000181855400089 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2372]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huo, HR,Guo, XM,Hong, SY,et al. Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2003,278(13):11561-11569. |
| APA | Huo, HR,Guo, XM,Hong, SY,Jiang, MR,Liu, XY,&Liao, K.(2003).Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction.JOURNAL OF BIOLOGICAL CHEMISTRY,278(13),11561-11569. |
| MLA | Huo, HR,et al."Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction".JOURNAL OF BIOLOGICAL CHEMISTRY 278.13(2003):11561-11569. |
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