IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice
文献类型：期刊论文
| 作者 | Wu, YD; Lin, Y; Hou, WQ; Wang, YP; Sun, B |
| 刊名 | JOURNAL OF NEUROIMMUNOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 137期号:1页码:154-163 |
| 关键词 | EAU IFN-gamma IL-12 receptor beta 2 |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Immunol, 320 Yueyang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12Rbeta2) expression was investigated in experimental autoimmune uveitis (EAU) susceptible B10.A and resistant BALB/c mice. B10.A mice expressed high IL-12Rbeta2 on T cells either in the disease target eyes or draining lymph node cells (LNC), and its expression correlated with the Th1-type response. In contrast, BALB/c mice only expressed minimal IL-12Rbeta2 in draining LNC and had lower Th1-response. B10.A mice produced more IFN-gamma and generated a higher number of Th1 cells than that of BALB/c in the draining LNC. Furthermore, IL-12Rbeta2 expression and STAT4 signaling were inhibited by anti-IFN-gamma mAb in the cultured draining LNC from B10.A mice, but enhanced by adding exogenous IFN-gamma in the cultured cells from BALB/c mice. The IL-12Rbeta2 expression on Th1 cells from draining LNC was increased in the presence of IL-12 and IFN-gamma. In conclusion, IFN-gamma production coffelated with IL-12beta2 expression on Th1-cells and IFN-gamma had a potential to regulate IL-12Rbeta2 expression in vivo. This regulatory mechanism might be involved in EAU induction. (C) 2003 Elsevier Science B.V. All rights reserved. |
| 学科主题 | Immunology; Neurosciences & Neurology |
| 类目[WOS] | Immunology ; Neurosciences |
| 关键词[WOS] | MESSENGER-RNA EXPRESSION ; CD4+ T-CELLS ; GENETIC SUSCEPTIBILITY ; ENDOGENOUS IL-12 ; TH2 CELLS ; IN-VIVO ; UVEORETINITIS ; DIFFERENTIATION ; MACROPHAGES ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000182443700019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2394]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, YD,Lin, Y,Hou, WQ,et al. IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice[J]. JOURNAL OF NEUROIMMUNOLOGY,2003,137(1):154-163. |
| APA | Wu, YD,Lin, Y,Hou, WQ,Wang, YP,&Sun, B.(2003).IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice.JOURNAL OF NEUROIMMUNOLOGY,137(1),154-163. |
| MLA | Wu, YD,et al."IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice".JOURNAL OF NEUROIMMUNOLOGY 137.1(2003):154-163. |
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