中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice

文献类型:期刊论文

作者Wu, YD; Lin, Y; Hou, WQ; Wang, YP; Sun, B
刊名JOURNAL OF NEUROIMMUNOLOGY
出版日期2003
卷号137期号:1页码:154-163
关键词EAU IFN-gamma IL-12 receptor beta 2
通讯作者Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Immunol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,
英文摘要IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12Rbeta2) expression was investigated in experimental autoimmune uveitis (EAU) susceptible B10.A and resistant BALB/c mice. B10.A mice expressed high IL-12Rbeta2 on T cells either in the disease target eyes or draining lymph node cells (LNC), and its expression correlated with the Th1-type response. In contrast, BALB/c mice only expressed minimal IL-12Rbeta2 in draining LNC and had lower Th1-response. B10.A mice produced more IFN-gamma and generated a higher number of Th1 cells than that of BALB/c in the draining LNC. Furthermore, IL-12Rbeta2 expression and STAT4 signaling were inhibited by anti-IFN-gamma mAb in the cultured draining LNC from B10.A mice, but enhanced by adding exogenous IFN-gamma in the cultured cells from BALB/c mice. The IL-12Rbeta2 expression on Th1 cells from draining LNC was increased in the presence of IL-12 and IFN-gamma. In conclusion, IFN-gamma production coffelated with IL-12beta2 expression on Th1-cells and IFN-gamma had a potential to regulate IL-12Rbeta2 expression in vivo. This regulatory mechanism might be involved in EAU induction. (C) 2003 Elsevier Science B.V. All rights reserved.
学科主题Immunology; Neurosciences & Neurology
类目[WOS]Immunology ; Neurosciences
关键词[WOS]MESSENGER-RNA EXPRESSION ; CD4+ T-CELLS ; GENETIC SUSCEPTIBILITY ; ENDOGENOUS IL-12 ; TH2 CELLS ; IN-VIVO ; UVEORETINITIS ; DIFFERENTIATION ; MACROPHAGES ; INHIBITION
收录类别SCI
语种英语
WOS记录号WOS:000182443700019
版本出版稿
源URL[http://202.127.25.143/handle/331003/2394]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Wu, YD,Lin, Y,Hou, WQ,et al. IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice[J]. JOURNAL OF NEUROIMMUNOLOGY,2003,137(1):154-163.
APA Wu, YD,Lin, Y,Hou, WQ,Wang, YP,&Sun, B.(2003).IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice.JOURNAL OF NEUROIMMUNOLOGY,137(1),154-163.
MLA Wu, YD,et al."IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice".JOURNAL OF NEUROIMMUNOLOGY 137.1(2003):154-163.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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