Interaction of Sedlin with chloride intracellular channel proteins
文献类型：期刊论文
| 作者 | Fan, LB; Yu, W; Zhu, XL |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 540期号:1页码:77-80 |
| 关键词 | CLIC1 Sedlin TRAPP complex interaction |
| 通讯作者 | Zhu, XL (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Sedlin is an evolutionarily conserved protein encoded by the causative gene SEDL for spondyloepiphyseal dysplasia tarda. Nevertheless, how Sedlin mutations cause the disease remains unknown. Here, the intracellular chloride channel protein CLIC1 was shown to associate with Sedlin by yeast two-hybrid screening. Green fluorescence protein-CLIC1 readily coimmunoprecipitated with FLAG-Sedlin. In addition, both proteins colocalized extensively in cytoplasmic vesicular/reticular structures in COS-7 cells, suggesting their interaction at intracellular membranous organelles: Sedlin also associated with CLIC2 in yeast two-hybrid assays. The link between Sedlin and the intracellular chloride channels is the first step to understand their functional interplays. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | SPONDYLOEPIPHYSEAL DYSPLASIA TARDA ; ION CHANNEL ; VESICLE DOCKING ; CLIC1 NCC27 ; TRAPP ; GENE ; GOLGI ; IDENTIFICATION ; EXPRESSION ; COMPLEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000182146900014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2398]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fan, LB,Yu, W,Zhu, XL. Interaction of Sedlin with chloride intracellular channel proteins[J]. FEBS LETTERS,2003,540(1):77-80. |
| APA | Fan, LB,Yu, W,&Zhu, XL.(2003).Interaction of Sedlin with chloride intracellular channel proteins.FEBS LETTERS,540(1),77-80. |
| MLA | Fan, LB,et al."Interaction of Sedlin with chloride intracellular channel proteins".FEBS LETTERS 540.1(2003):77-80. |
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