Identification of differentially expressed genes in human uterine leiomyomas using differential display
文献类型：期刊论文
| 作者 | Li, B; Sun, M; He, B; Yu, J; Zhang, YD; Zhang, YL |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 12期号:1页码:39-45 |
| 关键词 | human uterine leiomyomas differentially expressed gene differential display (DD) human S19 ribosomal protein (hRPS19) up-regulated gene in human leiomyomas |
| 通讯作者 | Zhang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | In searching of differentially expressed genes in human uterine leiomyomas, differential display was used with twelve pairs of primers to compare human uterine leiomyomas with matched myometrium. False positives were eliminated by reverse Northern analysis. Positives were confirmed by Northern blot analysis. RESULTS: [1] Four of 69 cDNA fragments (3 up-regulated named L1, L2 and L3 and 1 down-regulated named M1 in leiomyoma) were confirmed by Northern analysis. [21 Sequence comparison and Northern analysis proved that L1 is exactly the human ribosomal protein S19. [3] It was present ubiquitously in 13 tissues tested but in various levels and even in different size. [41 L1 was highly expressed in parotidean cystadenocarcinoma, pancreatic cancer and breast cancer examined. [5] No mutations have been found in human uterine leiomyomas (n=6). CONCLUSIONS: hRPS19 overexpression might be a universal signal in rapid cell growth tissues. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | S19 RIBOSOMAL-PROTEIN ; MESSENGER-RNA ; ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000174833300005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2417]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, B,Sun, M,He, B,et al. Identification of differentially expressed genes in human uterine leiomyomas using differential display[J]. CELL RESEARCH,2002,12(1):39-45. |
| APA | Li, B,Sun, M,He, B,Yu, J,Zhang, YD,&Zhang, YL.(2002).Identification of differentially expressed genes in human uterine leiomyomas using differential display.CELL RESEARCH,12(1),39-45. |
| MLA | Li, B,et al."Identification of differentially expressed genes in human uterine leiomyomas using differential display".CELL RESEARCH 12.1(2002):39-45. |
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