Secretory phospholipase A(2) inhibits epidermal growth factor-induced receptor activation
文献类型：期刊论文
| 作者 | Zhao, S; Du, XY; Chen, JS; Zhou, YC; Song, JG |
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 279期号:2页码:354-364 |
| 关键词 | secretory phospholipase A(2) epidermal growth factor ceramide sphingomyelinase phospholipase C-gamma(1) phospholipase D |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Box 25,320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Secretory phospholipase A(2) (sPLA(2)) plays important roles in mediating various cellular processes, including cell proliferation, differentiation, apoptosis, and inflammatory response. In this study, we demonstrated that a basic sPLA(2) inhibits epidermal growth factor (EGF)-induced EGF receptor activation, as determined by autophosphorylation of EGF receptor, EGF-activated phospholipase D (PLD) activity, and phospholipase C-gamma(1) (PLC-gamma(1)) tyrosine phosphorylation in a human epidermoid carcinoma cell line, A-431. Treatment of cells with exogenous neutral sphingomyelinase (SMase) or a cell permeable ceramide analog, C-2-ceramide, also caused similar inhibitory effects on EGF-induced activation of EGF receptor, tyrosine phosphorylation of PLC-gamma(1), and the activation of PLD. sPLA(2)-induced inhibition of EGF receptor was associated with arachidonic acid release, which was followed by an increase in intracellular ceramide formation. Both sPLA(2) and exogenous C-2-ceramide are able to inhibit the proliferation of A-431. The data presented indicate for the first time that sPLA(2) downregulates the EGF receptor-mediated intracellular signal transduction that may be mediated by arachidonic acid and/or ceramide. (C) 2002 Elsevier Science (USA). |
| 学科主题 | Oncology; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | NECROSIS-FACTOR-ALPHA ; DAUNORUBICIN-INDUCED APOPTOSIS ; MOUSE SMALL-INTESTINES ; CARCINOMA A431 CELLS ; ENHANCING FACTOR ; SIGNAL-TRANSDUCTION ; SPHINGOMYELIN HYDROLYSIS ; CERAMIDE GENERATION ; EGF RECEPTOR ; PHOSPHORYLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000178224700018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2433]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, S,Du, XY,Chen, JS,et al. Secretory phospholipase A(2) inhibits epidermal growth factor-induced receptor activation[J]. EXPERIMENTAL CELL RESEARCH,2002,279(2):354-364. |
| APA | Zhao, S,Du, XY,Chen, JS,Zhou, YC,&Song, JG.(2002).Secretory phospholipase A(2) inhibits epidermal growth factor-induced receptor activation.EXPERIMENTAL CELL RESEARCH,279(2),354-364. |
| MLA | Zhao, S,et al."Secretory phospholipase A(2) inhibits epidermal growth factor-induced receptor activation".EXPERIMENTAL CELL RESEARCH 279.2(2002):354-364. |
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