Further identification of NSF* as an epilepsy related gene
文献类型：期刊论文
| 作者 | Yu, FR; Guan, Z; Zhuo, M; Sun, LY; Zou, WG; Zheng, ZC; Liu, XY |
| 刊名 | MOLECULAR BRAIN RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 99期号:2页码:141-144 |
| 关键词 | N-ethylmaleimide-sensitive fusion protein (NSF) epilepsy related gene neurite outgrowth PC12 |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Previous data proved that NSF* was an epilepsy related gene (ERG1). In this study, using phosphorothioate oligodeoxynucleotide (PS-ODN), an antisense of NSF to downregulate the function of NSF in vitro cultured hippocampus neurons and PC12, this treatment simultaneously induced enhancement of the neurite outgrowth of hippocampal neurons and PC12, a phenomenon similar to the structural changes following epilepsy. Immunocytochemistry analysis showed that the enhancement of neurite outgrowth was in a sequence-specific manner and Northern blot confirmed that the decrease of NSF mRNA levels in PC12 was in a dose-dependent manner. Moreover the expression of NSF was downregulated during differentiation of PC12 induced by NGF and high KCl. Therefore, providing more evidence to support the fact that NSF was an ERG1. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | HIPPOCAMPAL MOSSY FIBER ; NEURITE OUTGROWTH ; AMPA RECEPTORS ; PC12 CELLS ; IN-VITRO ; CULTURES ; NEURONS ; SYSTEM ; GROWTH ; FUSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000175318200007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2444]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yu, FR,Guan, Z,Zhuo, M,et al. Further identification of NSF* as an epilepsy related gene[J]. MOLECULAR BRAIN RESEARCH,2002,99(2):141-144. |
| APA | Yu, FR.,Guan, Z.,Zhuo, M.,Sun, LY.,Zou, WG.,...&Liu, XY.(2002).Further identification of NSF* as an epilepsy related gene.MOLECULAR BRAIN RESEARCH,99(2),141-144. |
| MLA | Yu, FR,et al."Further identification of NSF* as an epilepsy related gene".MOLECULAR BRAIN RESEARCH 99.2(2002):141-144. |
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