CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cereivisiae
文献类型：期刊论文
| 作者 | Zhou, Z; Cao, F; Chen, JY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2002 |
| 卷号 | 34期号:3页码:298-304 |
| 关键词 | Candida albicans CaSRB9 gene FLO8 gene invasive growth filamentous growth |
| 通讯作者 | , |
| 英文摘要 | Candida albicans is the most frequently isolated fungal pathogen in humans. Many factors are involved in its morphological transition. Flo8 plays an important role in morphogenesis of Saccharomyces cerevisiae. In this work, a C. albicans genomic DNA library was introduced into an S. cerevisiae flo8/flo8 mutant to screen genes which could complement its invasive growth defect. In this screening, a novel gene was isolated and designated CaSRB9 (Candida albicans SRB9 gene). The CaSRB9 gene had an ORF of 4 998 bp, encoding a putative protein of 1 665 amino acids. The CaSrb9 shared highest similarity in amino acids (38%) with Srb9 of S. cerevisiae. Ectopic expression of the CaSPB9 gene in diploid S. cerevisiae suppressed defect in filamentous growth of some mutants in filamentation MAPK pathway ( ste7/ste7, ste12/ste12, and tec1/tec1) and flo8/flo8 mutant under nitrogen starvation conditions. In haploid S. cerevisiae, ectopic expressed CaSrb9 complemented the invasive growth defect of flo8 mutant but failed to complement the invasive growth defects of the mutants in filamentation MAPK pathway. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | RNA-POLYMERASE-II ; FILAMENTOUS GROWTH ; TRANSCRIPTIONAL REGULATION ; REPORTER GENE ; YEAST ; CEREVISIAE ; PROTEINS ; CLONING ; FAMILY ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000175697900007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2463]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, Z,Cao, F,Chen, JY. CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cereivisiae[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2002,34(3):298-304. |
| APA | Zhou, Z,Cao, F,&Chen, JY.(2002).CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cereivisiae.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,34(3),298-304. |
| MLA | Zhou, Z,et al."CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cereivisiae".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 34.3(2002):298-304. |
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