Subunit composition and function of GABA(A) receptors of rat spermatozoa
文献类型：期刊论文
| 作者 | Hu, JH; He, XB; Wu, Q; Yan, YC; Koide, SS |
| 刊名 | NEUROCHEMICAL RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 27期号:3页码:195-199 |
| 关键词 | acrosome reaction GABA(A) receptor agonist and antagonist chlortetracycline assay progesterone |
| 通讯作者 | Yan, YC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | GABA triggers mammalian sperm acrosome reaction (AR). Here, evidence is presented, showing that rat spermatozoa contain GABA(A) receptors, composed of alpha(5), beta(1), and beta(3) subunits. The effects of GABA(A) receptor agonist and antagonist on the induction of AR in rat spermatozoa were assessed using the chlortetracycline assay. Muscimol, a GABA(A) receptor agonist, triggered AR; whereas bicuculline, a GABA(A) receptor antagonist and picrotoxin, a GABA(A) receptor/Cl- channel blocker, inhibited the ability of GAGA or progesterone to induce AR. In conclusion, GABA(A) receptors appear to mediate the action of progesterone in inducing AR in rat spermatozoa. |
| 学科主题 | Biochemistry & Molecular Biology; Neurosciences & Neurology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 关键词[WOS] | GAMMA-AMINOBUTYRIC-ACID ; SPERM ACROSOME REACTION ; MOUSE SPERMATOZOA ; BINDING-SITES ; PROGESTERONE ; EXPRESSION ; CHLORTETRACYCLINE ; CAPACITATION ; EXOCYTOSIS ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000174854100003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2472]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, JH,He, XB,Wu, Q,et al. Subunit composition and function of GABA(A) receptors of rat spermatozoa[J]. NEUROCHEMICAL RESEARCH,2002,27(3):195-199. |
| APA | Hu, JH,He, XB,Wu, Q,Yan, YC,&Koide, SS.(2002).Subunit composition and function of GABA(A) receptors of rat spermatozoa.NEUROCHEMICAL RESEARCH,27(3),195-199. |
| MLA | Hu, JH,et al."Subunit composition and function of GABA(A) receptors of rat spermatozoa".NEUROCHEMICAL RESEARCH 27.3(2002):195-199. |
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