Synthesis of Ser-His-Gly-DNA conjugates
文献类型：期刊论文
| 作者 | Li, XQ; Liu, H; Zhuang, M; Tan, B; Zhao, YF; Lu, CD |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2002 |
| 卷号 | 34期号:4页码:506-511 |
| 关键词 | oligonucleotide backbone peptide Ser-His-Gly phosphoramidite |
| 通讯作者 | , |
| 英文摘要 | There are strong interactions between the bases of oligonucleotides. Based on Watson-Crick principle, they can form stable secondary and tertiary structure such as hairpin, duplex, triplex, G-quartet, pseudoknot, which can serve as the scaffold of molecules. Peptides contain active groups such as amino, carboxyl, imidazole, hydroxyl. A protected Ser-His-Gly-Threoninol phosphoramidite was synthesized in this work and was incorporated into a triplex-forming oligonucleotide. The results indicate that the oligonucleotide containing Ser-His-Gly-Threoninol in the middle could still form triplex with the target duplex and the dissociation constant was 0.5 mumol/L. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | AMINO-ACIDS ; OLIGONUCLEOTIDES ; PEPTIDES ; HYBRIDS |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000177017300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2486]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, XQ,Liu, H,Zhuang, M,et al. Synthesis of Ser-His-Gly-DNA conjugates[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2002,34(4):506-511. |
| APA | Li, XQ,Liu, H,Zhuang, M,Tan, B,Zhao, YF,&Lu, CD.(2002).Synthesis of Ser-His-Gly-DNA conjugates.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,34(4),506-511. |
| MLA | Li, XQ,et al."Synthesis of Ser-His-Gly-DNA conjugates".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 34.4(2002):506-511. |
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