Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells
文献类型：期刊论文
| 作者 | Yang, L; He, HY; Zhang, XJ |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 42期号:4页码:261-268 |
| 关键词 | acetylcholinesterase Alzheimer's disease apoptosis caspase-3 |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Programmed cell death plays an integral role in neurodegenerative diseases such as Alzheimer's disease (AD). Acetylcholinesterase (AChE) was suggested to be neurotoxic in vivo and in vitro and accelerate assembly of amyloid peptide into Alzheimer's fibrils. In our experiments, we found increased AChE expression in apoptotic neuroblastoma SK-N-SH cells after long-term culture. Our results first showed that in apoptotic SK-N-SH cells, AChE aggregated in the nucleus and suppression of AChE expression with antisense oligonucleotide could save the cells from apoptosis. It was also found that caspase-3 activity was parallel with AChE activation in apoptotic SK-N-SH cells. These results suggest that AChE plays an important role in the procession of neuroblastoma cell apoptosis and favor the association between AChE and neuronal apoptosis in AD. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | AMYLOID-BETA-PEPTIDE ; HUMAN PRIMARY NEURON ; ALZHEIMERS-DISEASE ; PRECURSOR PROTEIN ; NERVOUS-SYSTEM ; ACETYLCHOLINESTERASE ; CHOLINESTERASES ; BRAIN ; NEUROTOXICITY ; MECHANISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000175442000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2491]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, L,He, HY,Zhang, XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells[J]. NEUROSCIENCE RESEARCH,2002,42(4):261-268. |
| APA | Yang, L,He, HY,&Zhang, XJ.(2002).Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells.NEUROSCIENCE RESEARCH,42(4),261-268. |
| MLA | Yang, L,et al."Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells".NEUROSCIENCE RESEARCH 42.4(2002):261-268. |
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