A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P)
文献类型：期刊论文
| 作者 | Li, L; Qian, KX; Geng, JG |
| 刊名 | THROMBOSIS AND HAEMOSTASIS
 |
| 出版日期 | 2002 |
| 卷号 | 87期号:4页码:706-711 |
| 关键词 | platelets P-selectin (CD62P) thrombosis glycoprotein ligand |
| 通讯作者 | Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Room 505,320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | P-selectin (CD62P) is expressed on activated platelets and on stimulated endothelial cells. It interacts with P-selectin glycoprotein ligand-I (PSGL-1: CD162) for adhesion of activated platelets on leukocytes and for rolling of leukocytes on stimulated endothelial cells. Recently, resting and activated platelets have been shown to roll on endothelial P-selectin, indicating that platelets express (a) ligand(s) for P-selectin. Here we show that P-selectin specifically precipitated one 28-kDa glycoprotein from the whole cell 1 sates and the membrane lysates of human Platelets in a Ca2+-dependent manner. Further, the Purified 28-kDa molecule could inhibit the binding of P-selectin to human resting and activated platelets, In contrast, KPL1 (a leukocyte adhesion blocking MoAb to PSGL-1) did not neutralize the binding of P-selectin to human platelets. even though it abolished the binding of P-selectin to human promyeloid HL-60 cells. Our results thus indicate that the 28-kDa glycoprotein may function as an important platelet ligand for P-selectin. |
| 学科主题 | Hematology; Cardiovascular System & Cardiology |
| 类目[WOS] | Hematology ; Peripheral Vascular Disease |
| 关键词[WOS] | MONOCLONAL-ANTIBODY ; DEFICIENT MICE ; ADHESION ; COUNTERRECEPTOR ; THROMBOSIS ; PSGL-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000174981300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2492]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, L,Qian, KX,Geng, JG. A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P)[J]. THROMBOSIS AND HAEMOSTASIS,2002,87(4):706-711. |
| APA | Li, L,Qian, KX,&Geng, JG.(2002).A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P).THROMBOSIS AND HAEMOSTASIS,87(4),706-711. |
| MLA | Li, L,et al."A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P)".THROMBOSIS AND HAEMOSTASIS 87.4(2002):706-711. |
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