Gene expression of cytokine receptors in HL60 cells exposed to a 50 Hz magnetic field
文献类型：期刊论文
| 作者 | Zhou, JL; Li, CL; Yao, GD; Chiang, HA; Chang, ZL |
| 刊名 | BIOELECTROMAGNETICS
 |
| 出版日期 | 2002 |
| 卷号 | 23期号:5页码:339-346 |
| 关键词 | TNF receptor IL-6 receptor TGF beta receptor interleukin-6 tumor necrosis factor transforming growth factor |
| 通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Immune Signal transduct, Shanghai 200031, Peoples R China., |
| 英文摘要 | dThe effects of a 50 Hz extremely low frequency (ELF) sinusoidal magnetic field (MF) on the expression of genes relating to cytokine receptors were studied in HL60 cells. Transcription levels of tumor necrosis factor receptor (TNFR) p55 and p75, interleukin-6 receptor-alpha (IL-6Ralpha) and transforming growth factor-beta receptor I (TGFbetaR1) were quantified in cells exposed to an intensity of 0.1 or 0.8 mT for periods ranging from 30 min to 72 h. Cells treated with 10 nM of phorbol 12-myristate 13-acetate (PMA) for 8 h served as a positive control. Gene expression values were assessed by the ribonuclease protection assay (RPA) and normalized to those of the noninducible gene GAPDH. The results showed that MF exposure at 0.1 and 0.8 mT for 72 h increased TNFR p75 and IL-6Ralpha mRNA expression in HL60 cells. No significant change in gene expression levels of TNFR p55 and TGFbetaR1 was observed under any of the exposure conditions. In addition. we report here for the first time that IL-6Ralpha mRNA expression can be suppressed by PMA in HL60 cells. (C) 2002 Wiley-Liss, Inc. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics; Biophysics |
| 类目[WOS] | Biology ; Biophysics |
| 关键词[WOS] | FREQUENCY ELECTROMAGNETIC-FIELDS ; ELECTRIC UTILITY WORKERS ; OCCUPATIONAL EXPOSURE ; HL-60 CELLS ; EPIDEMIOLOGIC EVIDENCE ; HUMAN-LYMPHOCYTES ; CANCER MORTALITY ; MACROPHAGE-LIKE ; LEUKEMIA-CELLS ; BREAST-CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000176673800002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2510]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, JL,Li, CL,Yao, GD,et al. Gene expression of cytokine receptors in HL60 cells exposed to a 50 Hz magnetic field[J]. BIOELECTROMAGNETICS,2002,23(5):339-346. |
| APA | Zhou, JL,Li, CL,Yao, GD,Chiang, HA,&Chang, ZL.(2002).Gene expression of cytokine receptors in HL60 cells exposed to a 50 Hz magnetic field.BIOELECTROMAGNETICS,23(5),339-346. |
| MLA | Zhou, JL,et al."Gene expression of cytokine receptors in HL60 cells exposed to a 50 Hz magnetic field".BIOELECTROMAGNETICS 23.5(2002):339-346. |
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