Interleukin-2 gene has superior antinociceptive effects when delivered intrathecally
文献类型：期刊论文
| 作者 | Yao, MZ; Wang, JH; Gu, JF; Sun, LY; Liu, H; Zhao, ZQ; Liu, XY |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2002 |
| 卷号 | 13期号:6页码:791-794 |
| 关键词 | antinociceptive effect gene therapy interleukin-2 intrathecal delivery pain subcutaneous delivery |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | The antinociceptive effect of interleukin-2 gene on rat carrageenan-induced pain was explored using different delivery methods. Intrathecal (i.t) or plantar s.c. delivery of plasmid harbouring the interleukin-2 gene produced a marked antinociceptive effect, which was maintained up to 6 days; the administration of recombinant human interleukin-2 only had a transitory effect. The antinociceptive effect lasted longer and was more potent when the interleukin-2 gene was administered i.t. than when delivered s.c. The effect of the interleukin-2 gene was related to its protein expression, was dose dependent, and could be potentiated by liposome. The results suggest that the interleukin-2 gene has a good prospect for clinical use. NeuroReport 13:791-794 (C) 2002 Lippincott Williams Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | IL-2 ; EXPRESSION ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000175442400013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2521]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yao, MZ,Wang, JH,Gu, JF,et al. Interleukin-2 gene has superior antinociceptive effects when delivered intrathecally[J]. NEUROREPORT,2002,13(6):791-794. |
| APA | Yao, MZ.,Wang, JH.,Gu, JF.,Sun, LY.,Liu, H.,...&Liu, XY.(2002).Interleukin-2 gene has superior antinociceptive effects when delivered intrathecally.NEUROREPORT,13(6),791-794. |
| MLA | Yao, MZ,et al."Interleukin-2 gene has superior antinociceptive effects when delivered intrathecally".NEUROREPORT 13.6(2002):791-794. |
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