Bioinformatic analysis of human nuclear receptor nr5a2(hb1f) genomic sequence
文献类型：期刊论文
| 作者 | Zhang, CK; Lin, W; Cai, YN; Dong, H; Li, M; Fu, G; Xie, YH; Huang, MGY; Wang, YA |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2002 |
| 卷号 | 47期号:7页码:568-572 |
| 关键词 | nuclear receptor nr5a2(hb1f) gene structure bioinformatics comparative genomics |
| 通讯作者 | Wang, YA (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | We have cloned the cDNA of human nuclear receptor nr5a2(hb1f) gene and obtained its whole genomic sequence previously. In this work we carried out in-depth bioinformatic analysis on the genomic sequence of nr5a2(hb1f) gene. Sequence comparison and prediction algorithms implicated that there might be additional coding regions in the 210 kb genomic sequence besides known exons, especially in the two largest introns. Comparison of the structures of nr5a loci in different species revealed distinguishable conservation and apparent gene duplication during evolution. The remarkable conservation among promoters of zebrafish, mouse and human nr5a2 genes suggested that they would be regulated by the same transcription factors. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | FETOPROTEIN TRANSCRIPTION FACTOR ; STEROIDOGENIC FACTOR-1 ; GENE ; PROMOTER ; HB1F ; CLONING ; FTF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000175219200011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2526]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, CK,Lin, W,Cai, YN,et al. Bioinformatic analysis of human nuclear receptor nr5a2(hb1f) genomic sequence[J]. CHINESE SCIENCE BULLETIN,2002,47(7):568-572. |
| APA | Zhang, CK.,Lin, W.,Cai, YN.,Dong, H.,Li, M.,...&Wang, YA.(2002).Bioinformatic analysis of human nuclear receptor nr5a2(hb1f) genomic sequence.CHINESE SCIENCE BULLETIN,47(7),568-572. |
| MLA | Zhang, CK,et al."Bioinformatic analysis of human nuclear receptor nr5a2(hb1f) genomic sequence".CHINESE SCIENCE BULLETIN 47.7(2002):568-572. |
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