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Induction of acetylcholinesterase expression during apoptosis in various cell types
文献类型：期刊论文
| 作者 | Zhang, XJ; Yang, L; Zhao, Q; Caen, JP; He, HY; Jin, QH; Guo, LH; Alemany, M; Zhang, LY; Shi, YF |
| 刊名 | CELL DEATH AND DIFFERENTIATION
 |
| 出版日期 | 2002 |
| 卷号 | 9期号:8页码:790-800 |
| 关键词 | apoptosis acetylcholinesterase noncholinergic |
| 通讯作者 | Shi, YF (reprint author), Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Microbiol Mol Genet & Immunol, 661 Hoes Lane, Piscataway, NJ 08854 USA., |
| 英文摘要 | Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission. It has been suggested that AChE may participate in development, differentiation, and pathogenic processes such as Alzheimer's disease and tumorigenesis. We examined AChE expression in a number of cell lines upon induction of apoptosis by various stimuli. AChE is induced in all apoptotic cells examined as determined by cytochemical staining, immunological analysis, affinity chromatography purification, and molecular cloning. The AChE protein was found in the cytoplasm at the initiation of apoptosis and then in the nucleus or apoptotic bodies upon commitment to cell death. Sequence analysis revealed that AChE expressed in apoptotic cells is identical to the synapse type AChE. Pharmacological inhibitors of AChE prevented apoptosis. Furthermore, blocking the expression of AChE with antisense inhibited apoptosis. Therefore, our studies demonstrate that AChE is potentially a marker and a regulator of apoptosis. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | ALZHEIMERS-DISEASE ; CHOLINESTERASES ; GENE ; 7Q22 ; DIFFERENTIATION ; CANCER ; DEATH ; RAT ; MEGAKARYOCYTES ; HETEROZYGOSITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000176908300003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2527]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, XJ,Yang, L,Zhao, Q,et al. Induction of acetylcholinesterase expression during apoptosis in various cell types[J]. CELL DEATH AND DIFFERENTIATION,2002,9(8):790-800. |
| APA | Zhang, XJ.,Yang, L.,Zhao, Q.,Caen, JP.,He, HY.,...&Shi, YF.(2002).Induction of acetylcholinesterase expression during apoptosis in various cell types.CELL DEATH AND DIFFERENTIATION,9(8),790-800. |
| MLA | Zhang, XJ,et al."Induction of acetylcholinesterase expression during apoptosis in various cell types".CELL DEATH AND DIFFERENTIATION 9.8(2002):790-800. |
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