Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells
文献类型：期刊论文
| 作者 | Ji, LL; Zhao, XG; Chen, L; Zhang, M; Wang, ZT |
| 刊名 | TOXICON
 |
| 出版日期 | 2002 |
| 卷号 | 40期号:12页码:1685-1690 |
| 关键词 | clivorine pyrrolizidine alkaloid L-02 cell p38 mitogen-activated protein kinase |
| 通讯作者 | Chen, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China., |
| 英文摘要 | Clivorine, a pyrrolizidine alkaloid extracted from Chinese medicinal plant Ligularia hodgsonii Hook significantly inhibited human normal liver L-02 cells proliferation and decreased L-02 cells viability. The results of western blot showed that clivorine strongly evoked phosphorylation of p38 mitogen-activated protein (MAP) Kinase in L-02 cells, but had no effect on extracellular signal-related kinases MAP Kinase phosphorylation. Moreover, another pyrrolizidine alkaloid monocrotaline had no effect on phosphorylation of p38 MAP Kinase in L-02 cells. These studies document the effects of pyrrolizidine alkaloid clivorine on the MAPK cascade and on the growth of human normal liver L-02 cells for the first time, which may be a possible reason for the toxic effects observed in those plants containing pyrrolizidine alkaloids. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | SMOOTH-MUSCLE CELLS ; INDUCED APOPTOSIS ; SIGNALING PATHWAY ; ENDOTHELIAL-CELLS ; MAP KINASES ; DNA ; PHOSPHORYLATION ; DEATH ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000180152300006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2538]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ji, LL,Zhao, XG,Chen, L,et al. Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells[J]. TOXICON,2002,40(12):1685-1690. |
| APA | Ji, LL,Zhao, XG,Chen, L,Zhang, M,&Wang, ZT.(2002).Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells.TOXICON,40(12),1685-1690. |
| MLA | Ji, LL,et al."Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells".TOXICON 40.12(2002):1685-1690. |
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