(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro
文献类型：期刊论文
| 作者 | Guo, H; Yu, Y; Xing, L; Jin, GZ; Zhou, JW |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2002 |
| 卷号 | 13期号:16页码:2085-2089 |
| 关键词 | differentiation neural precursor cells rat stepholidine tyrosine hydroxylase tissue culture |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Key Lab Proteom, Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | The present study investigated the influence of (-)-stepholidine, an effective dopamine D-1 receptor agonist and D-2 receptor antagonist, on the development of neural precursor cells. Incubation of striatal neural precursor cells with stepholidine resulted in significant increase in the number of proliferating precursor cell spheres when in the presence of fibroblast growth factor-2. This action can be blocked by application of haloperidol. Treatment with stepholidine also increased the number of microtubule-associated protein-2-immunoreactive cells in the cultures and promoted marked increases in tyrosine hydroxylase expression. These findings suggest that stepholidine is involved in the regulation of proliferation of precursor cells. The effect appears to be mediated by dopamine receptors. Stepholidine also promotes the differentiation of precursor cells, however, this action may be independent of its effect on dopaminergic receptors. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | TYROSINE-HYDROXYLASE EXPRESSION ; CILIARY NEUROTROPHIC FACTOR ; FIBROBLAST GROWTH FACTOR-2 ; NEURAL STEM-CELL ; DOPAMINERGIC PHENOTYPE ; IN-VITRO ; GENERATION ; FOREBRAIN ; INDUCTION ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000179821600019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2540]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Guo, H,Yu, Y,Xing, L,et al. (-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro[J]. NEUROREPORT,2002,13(16):2085-2089. |
| APA | Guo, H,Yu, Y,Xing, L,Jin, GZ,&Zhou, JW.(2002).(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro.NEUROREPORT,13(16),2085-2089. |
| MLA | Guo, H,et al."(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro".NEUROREPORT 13.16(2002):2085-2089. |
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