The associated regulators and signal pathway in rIL-16/CD4 mediated growth regulation in Jurkat cells
文献类型：期刊论文
| 作者 | Zhang, XM; Xu, YH |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 12期号:1页码:363-372 |
| 关键词 | IL-16 Jurkat cells growth regulation |
| 通讯作者 | Xu, YH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Mol & Cellular Oncol, Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | IL-16 is a ligand and chemotactic factor for CD4(+) T cells. IL-16 inhibits the CD3 mediated lymphocyte activation and proliferation. The effects of IL-16 on the target cells are dependent on the cell type, the presence of co-activators etc. To understand the regulation function and mechanism of IL-16 on target cells, we used a 130 a.a. recombinant IL-16 to study its effects on the growth of Jurkat T leukemia cells in vitro. We found that the rIL-16 stimulated the proliferation of Jurkat cells at low dose (10(-9)M, but inhibited the growth of the cells at higher concentration (10(-5)M. Results showed that 10(-5) M of rIL-16 treatment induced an enhanced apoptosis in Jurkat cells. The treatment blocked the expression of FasL, but up-regulated the c-myc and Bid expression in the cells. Pre-treatment of PKC inhibitor or MEK1 inhibitor markedly increased or decreased the rIL-16 induced growth-inhibiting effects on Jurkat cells, respectively. The results suggested that the rIL-16 might be a regulator for the growth or apoptosis of Jurkat cells at a dose-dependent manner. The growth-inhibiting effects of rIL-16 might be Fas/FasL independent, but, associated with the activation of PKC, up-regulated expression of c-Myc and Bid, and the participation of the ERK signal pathway in Jurkat cells. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | LYMPHOCYTE CHEMOATTRACTANT FACTOR ; ACTIVATION-INDUCED APOPTOSIS ; CD4(+) T-CELLS ; ORPHAN STEROID-RECEPTOR ; DEATH RECEPTOR ; CROSS-LINKING ; IL-16 ; EXPRESSION ; INTERLEUKIN-16 ; LIGAND |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000180476800006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2563]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, XM,Xu, YH. The associated regulators and signal pathway in rIL-16/CD4 mediated growth regulation in Jurkat cells[J]. CELL RESEARCH,2002,12(1):363-372. |
| APA | Zhang, XM,&Xu, YH.(2002).The associated regulators and signal pathway in rIL-16/CD4 mediated growth regulation in Jurkat cells.CELL RESEARCH,12(1),363-372. |
| MLA | Zhang, XM,et al."The associated regulators and signal pathway in rIL-16/CD4 mediated growth regulation in Jurkat cells".CELL RESEARCH 12.1(2002):363-372. |
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