An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis
文献类型：期刊论文
| 作者 | Mei, WY; Yang, J; Tao, QH; Geng, X; Rupp, RAW; Ding, XY |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2001 |
| 卷号 | 505期号:1页码:47-52 |
| 关键词 | interferon regulatory factor binding element promoter gastrula myogenesis Xenopus myf-5 |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | The expression of myf-5, a key component of myogenic regulatory genus, declines progressively in mature somitic cells during, vertebrate myogenesis. Little is known about how this down-regulation takes place. Here we provide evidence that an interferon regulatory factor binding element (IRF element) within the Xenopus myf-5 promoter is responsible for the elimination of myf-5 transcription in mature somitic mesoderm of Xenopus embryos. We show that this IRF element mediates the down-regulation of Xmyf-5 transcription in gastrula embryos, and can specifically interact with nuclear proteins of early neurula. Moreover, deletion of this IRF element results in the anterior expansion of reporter gene transcripts within somitic mesoderm in transgenic embryos. Our results, therefore, provide insight into how the negative control of Xmyf-5 expression takes place. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | SKELETAL-MUSCLE ; GENE MYF-5 ; IRF-1 ; IFN ; CELLS ; INDUCTION ; EMBRYO ; DIFFERENTIATION ; INACTIVATION ; MORPHOGEN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171084200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2573]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mei, WY,Yang, J,Tao, QH,et al. An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis[J]. FEBS LETTERS,2001,505(1):47-52. |
| APA | Mei, WY,Yang, J,Tao, QH,Geng, X,Rupp, RAW,&Ding, XY.(2001).An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis.FEBS LETTERS,505(1),47-52. |
| MLA | Mei, WY,et al."An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis".FEBS LETTERS 505.1(2001):47-52. |
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