Inhibition of Th1-and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages
文献类型：期刊论文
| 作者 | Xu, WF; Hou, WQ; Yao, G; Ji, YY; Yeh, M; Sun, B |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 284期号:1页码:168-172 |
| 关键词 | trichosanthin tumor necrosis factor-alpha interleukin-12 interleukin-10 monocyte chemoattractant protein-1 macrophage lipopolysaccharide T helper 1 T helper 2 immunoglobulin E |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Lab Mol Immunol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China., |
| 英文摘要 | Trichosanthin (TCS), the major effective component from Chinese herb Trichosanthes Kirilowii Maxim, is also a potent allergen. Our previous work has shown that TCS can upregulate interleukin-4 (IL-4) and interleukin-13 (IL-13) while inhibit interferon-gamma (IFN-gamma) in mesenteric lymph node cells after TCS immunization. Thus, TCS can arouse a T helper 2 (Th2) response in the draining lymph node. However, little is known about the early effects of TCS on antigen-presenting cells, the initiator of T cell response. In the current study, the effects of TCS on macrophage cytokines and chemokine expression were investigated. Peritoneal macrophages were treated with or without TCS in the presence of lipopolysaccharide (LPS). We found that TCS increased macrophage interleukin-10 (IL-10) and monocyte chemoattractant protein-1 (MCP-1) expression, whereas it decreased interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) expression. Our study clearly demonstrated that TCS, as an allergen, has differential effects on macrophage Th1/Th2 initiative factors, effects that are likely to facilitate its inducing of Th2 and immunoglobulin E (IgE) response. (C) 2001 Academic Press. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; RESPONSES IN-VIVO ; CD4+ T-CELLS ; TNF-ALPHA ; TH1 ; IL-12 ; EXPRESSION ; IMMUNITY ; COMPLEX ; GAMMA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000169232500025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2575]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, WF,Hou, WQ,Yao, G,et al. Inhibition of Th1-and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,284(1):168-172. |
| APA | Xu, WF,Hou, WQ,Yao, G,Ji, YY,Yeh, M,&Sun, B.(2001).Inhibition of Th1-and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,284(1),168-172. |
| MLA | Xu, WF,et al."Inhibition of Th1-and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284.1(2001):168-172. |
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