Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor
文献类型：期刊论文
| 作者 | Lu, L; Su, WJ; Yue, W; Ge, X; Su, F; Pei, G; Ma, L |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2001 |
| 卷号 | 69期号:1页码:37-46 |
| 关键词 | serotonin/noradrenaline reuptake inhibitor opiate dependence withdrawal conditioned place preference relapse |
| 通讯作者 | Ma, L (reprint author), Fudan Univ, Med Ctr, Natl Lab Med Neurobiol, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China., |
| 英文摘要 | The effects of venlafaxine, a novel serotonin and adrenaline reuptake inhibitor, on the morphine withdrawal and activation of morphine conditioned place preference (CPP), were investigated in rats. Our results showed that the most morphine withdrawal signs, including jumping, writhing, shakes, exploring, lacrimation, piloerection, irritability, and diarrhea, were attenuated by pretreatment with 10 or 20 mg/kg venlafaxine. To investigate the effects of venlafaxine on relapse to opiate dependence, the morphine CPP was used and a dopamine D2 antagonist sulpiride was selected as a control drug. The morphine CPP disappeared following a 28-day drug-free period and appeared again after given a single injection of 1 mg/kg morphine. Acute treatment with sulpiride (25 or 50 mg/kg, i.p.) 30 min prior to 1 mg/kg morphine injection significantly blocked the reacquisition of CPP, while venlafaxine (10 or 20 mg/kg, i.p.) did not show significant effect. However, chronic treatment with venlafaxine (5 or 10 mg/kg, i.p. twice, daily, for seven consecutive days) significantly attenuated the reacquisition of morphine CPP, whereas chronic treatment with sulpiride (10 or 20 mg/kg, i.p.) have no significant effect. Our results demonstrated for the first time that venlafaxine strongly attenuates morphine withdrawal and morphine-induced reaquisition of CPP in rats and suggest that venlafaxine. an effective novel antidepressive drug, may have therapeutic potential in treatment and prevention of relapse to opiate dependence. (C) 2001 Elsevier Science Inc. All rights reserved. |
| 学科主题 | Research & Experimental Medicine; Pharmacology & Pharmacy |
| 类目[WOS] | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 关键词[WOS] | CORTICOTROPIN-RELEASING FACTOR ; STRESS-INDUCED RELAPSE ; ANTAGONIST ; COCAINE ; OPIATE ; SEEKING ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000169028500004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2576]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lu, L,Su, WJ,Yue, W,et al. Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor[J]. LIFE SCIENCES,2001,69(1):37-46. |
| APA | Lu, L.,Su, WJ.,Yue, W.,Ge, X.,Su, F.,...&Ma, L.(2001).Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor.LIFE SCIENCES,69(1),37-46. |
| MLA | Lu, L,et al."Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor".LIFE SCIENCES 69.1(2001):37-46. |
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