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Identification and cellular localization of human PFTAIRE1

文献类型：期刊论文

作者Yang, T; Chen, JY
刊名GENE
出版日期2001
卷号267期号:2页码:165-172
关键词hPFTAIRE1 Cdc2-related protein kinase chromosome 7q21.13 cytoplasmic distribution green fluorescent protein
通讯作者Chen, JY (reprint author), Chinese Acad Sci, Shanghai Inst BIol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,
英文摘要We isolated a novel member of putative Cdc2-related serine/threonine protein kinases from a Hela cell cDNA library. The cDNA encodes a protein of 469 amino acids, sharing 95% identities with the mouse PFTAIRE1 throughout the entire protein sequence. This gene was designated human PFTAIREI. The gene was located at human chromosome 7q21.13 with radiation hybrid polyermase chain reaction (RH-PCR) analysis. By Northern blotting analysis, a -6 kb transcript is detected with varied levels of expression of the hPFTAIRE1 in 16 human tissues. The hPFTAIRE1 was highly expressed in brain, pancreas, kidney, heart, testis and ovary. The transcript was also detected at lower level in other tissues, except in spleen and thymus where the transcript was hardly detected. The protein was fused to the C-terminus of a green fluorescent protein (GFP) and ectopically expressed in Hela cells. The florescence microscope results indicated that the hPFTAIRE1 exhibits cytoplasmic distribution. (C) 2001 Elsevier Science B.V. All rights reserved.
学科主题Genetics & Heredity
类目[WOS]Genetics & Heredity
关键词[WOS]CDK FAMILY MEMBER ; PROTEIN-KINASE ; SERINE/THREONINE KINASE ; FISSION YEAST ; CYCLE ; MITOSIS ; PHOSPHORYLATION ; TRANSITION ; PCTAIRE-1 ; SUGGEST
收录类别SCI
语种英语
WOS记录号WOS:000168416600003
版本出版稿
源URL[http://202.127.25.143/handle/331003/2604]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714		 Yang, T,Chen, JY. Identification and cellular localization of human PFTAIRE1[J]. GENE,2001,267(2):165-172.
APA Yang, T,&Chen, JY.(2001).Identification and cellular localization of human PFTAIRE1.GENE,267(2),165-172.
MLA Yang, T,et al."Identification and cellular localization of human PFTAIRE1".GENE 267.2(2001):165-172.

入库方式： OAI收割

来源：上海生物化学与细胞生物学研究所

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