Cloning and characterization of fup1, a gene highly expressed in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Pan, W; Xi, QS; Xia, SL; Zhao, MJ; Gan, RB; Li, ZP |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2001 |
| 卷号 | 33期号:2页码:173-178 |
| 关键词 | hepatocellular carcinoma fup1 cloning tissue specificity transfection |
| 通讯作者 | , |
| 英文摘要 | Primary hepatocellular carcinoma(HCC) is one of the common malignant tumors in China. In our previous work, a gene named fup1(function-unknown protein 1) was isolated that was expressed differently in HCC and in normal liver. We assumed that it might be a candidate oncogene for the HCC. The fup1 gene had a ORF of 1 233 bp, encoding a protein with M-r of 46 kD and isoelectric paint of 5.48. The sequence characteristics showed its possible localization in nuclei. Northern blots showed that: this gene was weakly expressed in many types of human tissues, except in the heart, implying its tissue-specific expression pattern. MTT assay of the NIH 3T3 cells transfected with this gene in the form of recombinant eukaryotic expression plasmid showed its enhancing role to cellular proliferation. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | NUCLEAR FACTOR ; MUTATION ; SEQUENCE ; PROMOTER |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000167681800005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2608]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Pan, W,Xi, QS,Xia, SL,et al. Cloning and characterization of fup1, a gene highly expressed in hepatocellular carcinoma[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2001,33(2):173-178. |
| APA | Pan, W,Xi, QS,Xia, SL,Zhao, MJ,Gan, RB,&Li, ZP.(2001).Cloning and characterization of fup1, a gene highly expressed in hepatocellular carcinoma.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,33(2),173-178. |
| MLA | Pan, W,et al."Cloning and characterization of fup1, a gene highly expressed in hepatocellular carcinoma".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 33.2(2001):173-178. |
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