Activation of DNA damage checkpoints in CHO cells requires a certain level of DNA damage
文献类型：期刊论文
| 作者 | Jiang, MR; Yang, Y; Wu, JR |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 287期号:3页码:775-780 |
| 关键词 | checkpoint DNA damage DNA repair cell-cycle CHO cell |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Res Ctr,State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | DNA damage activates checkpoint controls in eukaryotic cells. It is not clear, however, whether a certain level of DNA damage is required for the activation of DNA damage checkpoints. We show here that low levels of DNA damage in Chinese hamster ovary (CHO) cells induced by short exposure to hydroxyurea (HU) did not trigger checkpoints, whereas higher levels of DNA damage caused by longer exposure to HU resulted in a cell cycle arrest. Our results argue that a threshold of DNA damage is necessary for activation of DNA damage checkpoints. (C) 2001 Academic Press. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SACCHAROMYCES-CEREVISIAE ; S-PHASE ; SCHIZOSACCHAROMYCES-POMBE ; PROTEIN-KINASES ; REPLICATION ; HYDROXYUREA ; INITIATION ; YEAST ; PROGRESSION ; MECHANISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171400200029 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2617]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, MR,Yang, Y,Wu, JR. Activation of DNA damage checkpoints in CHO cells requires a certain level of DNA damage[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,287(3):775-780. |
| APA | Jiang, MR,Yang, Y,&Wu, JR.(2001).Activation of DNA damage checkpoints in CHO cells requires a certain level of DNA damage.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,287(3),775-780. |
| MLA | Jiang, MR,et al."Activation of DNA damage checkpoints in CHO cells requires a certain level of DNA damage".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 287.3(2001):775-780. |
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