中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells

文献类型:期刊论文

作者Xia, YF; Liu, LP; Zhong, CP; Geng, JG
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2001
卷号289期号:4页码:851-856
关键词VCAM-1 ICAM-1 adhesion molecules B-lymphocytes plasma cells NF-kappa B transcriptional regulation
通讯作者Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Room 505,320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要Cytokine stimulation can activate NF-kappaB that triggers inducible expression of E-selectin, VCAM-1 (Vascular Cell Adhesion Molecule-1) and ICAM-1 (Intercellular Cell Adhesion Molecule-1) in endothelial cells. In the previous study, we have shown that B lymphocytes and plasma cells can express E-selectin by constitutive activation of NF-kappaB. Here we show that human B lymphocytes and ARH-77 plasma cells expressed VCAM-1 and ICAM-1 in a cytokine dispensable mechanism. NF-kappaB antagonists could inhibit their expressions in ARH-77 cells. The activities of NF-kappaB for VCAM-1 and ICAM-1 promoters prior to cytokine stimulation were detected in ARH-77 cells using electrophoretic mobility shift assays. Again, NF-kappaB antagonists could abrogate these promoter activities. Taken together, our results demonstrate that NF-kappaB activation is the underlying molecular mechanism for constitutive expression of E-selectin, VCAM-1, and ICAM-1 on human B lymphocytes and plasma cells. (C) 2001 Elsevier Science.
学科主题Biochemistry & Molecular Biology; Biophysics
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INTERCELLULAR-ADHESION MOLECULE-1 ; HUMAN ENDOTHELIAL-CELLS ; NECROSIS-FACTOR-ALPHA ; TRANSCRIPTION FACTOR ; E-SELECTIN ; DIFFERENTIAL REGULATION ; CONSERVED SEQUENCE ; LEUKOCYTE ADHESION ; GENE-EXPRESSION ; P-SELECTIN
收录类别SCI
语种英语
WOS记录号WOS:000173212200013
版本出版稿
源URL[http://202.127.25.143/handle/331003/2638]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
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GB/T 7714
Xia, YF,Liu, LP,Zhong, CP,et al. NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,289(4):851-856.
APA Xia, YF,Liu, LP,Zhong, CP,&Geng, JG.(2001).NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,289(4),851-856.
MLA Xia, YF,et al."NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289.4(2001):851-856.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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