NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells
文献类型：期刊论文
| 作者 | Xia, YF; Liu, LP; Zhong, CP; Geng, JG |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 289期号:4页码:851-856 |
| 关键词 | VCAM-1 ICAM-1 adhesion molecules B-lymphocytes plasma cells NF-kappa B transcriptional regulation |
| 通讯作者 | Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Room 505,320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Cytokine stimulation can activate NF-kappaB that triggers inducible expression of E-selectin, VCAM-1 (Vascular Cell Adhesion Molecule-1) and ICAM-1 (Intercellular Cell Adhesion Molecule-1) in endothelial cells. In the previous study, we have shown that B lymphocytes and plasma cells can express E-selectin by constitutive activation of NF-kappaB. Here we show that human B lymphocytes and ARH-77 plasma cells expressed VCAM-1 and ICAM-1 in a cytokine dispensable mechanism. NF-kappaB antagonists could inhibit their expressions in ARH-77 cells. The activities of NF-kappaB for VCAM-1 and ICAM-1 promoters prior to cytokine stimulation were detected in ARH-77 cells using electrophoretic mobility shift assays. Again, NF-kappaB antagonists could abrogate these promoter activities. Taken together, our results demonstrate that NF-kappaB activation is the underlying molecular mechanism for constitutive expression of E-selectin, VCAM-1, and ICAM-1 on human B lymphocytes and plasma cells. (C) 2001 Elsevier Science. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | INTERCELLULAR-ADHESION MOLECULE-1 ; HUMAN ENDOTHELIAL-CELLS ; NECROSIS-FACTOR-ALPHA ; TRANSCRIPTION FACTOR ; E-SELECTIN ; DIFFERENTIAL REGULATION ; CONSERVED SEQUENCE ; LEUKOCYTE ADHESION ; GENE-EXPRESSION ; P-SELECTIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000173212200013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2638]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xia, YF,Liu, LP,Zhong, CP,et al. NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,289(4):851-856. |
| APA | Xia, YF,Liu, LP,Zhong, CP,&Geng, JG.(2001).NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,289(4),851-856. |
| MLA | Xia, YF,et al."NF-kappa B activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289.4(2001):851-856. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。