Phorbol ester induces formation of a new phospholipase D product
文献类型：期刊论文
| 作者 | Chai, MQ; Chen, JS; Song, JG |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2001 |
| 卷号 | 33期号:4页码:395-400 |
| 关键词 | phospholipase D protein kinase C sphingolipid sphingomyclinase |
| 通讯作者 | , |
| 英文摘要 | It is demonstrated here that phorbol-12-myristate-13-acetate (PMA) induced the formation of a butanolated-sphingolipids in A-549 cells. In cells labeled with [H-3]-serine, the distribution of the radioactivity was easily found in phosphatidylcholine (PC), phosphatidylserine ( PS) and phosphatidylethanolamine ( PE), but not in phosphatidic acid (PA) and its immediate metabolic derivatives, suggesting that the newly detected PLD products were derived from sphingolipids and were different front the conventional product of PLD. Protein kinase C (PKC) inhibitors or PKC down-regulation by prolonged PMA treatment inhibited the PMA-induced generation of this butanolated-sphingolipid, indicating that PKC activation was required in this process. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | PROTEIN-KINASE-C ; SIGNAL-TRANSDUCTION ; GROWTH-FACTOR ; CROSS-TALK ; CELLS ; INHIBITION ; ACTIVATION ; BETA ; LYSOPHOSPHATIDATE ; PHOSPHATIDATE |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000170070500006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2648]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chai, MQ,Chen, JS,Song, JG. Phorbol ester induces formation of a new phospholipase D product[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2001,33(4):395-400. |
| APA | Chai, MQ,Chen, JS,&Song, JG.(2001).Phorbol ester induces formation of a new phospholipase D product.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,33(4),395-400. |
| MLA | Chai, MQ,et al."Phorbol ester induces formation of a new phospholipase D product".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 33.4(2001):395-400. |
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