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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
文献类型：期刊论文
| 作者 | Mao, JH; Wang, JY; Liu, B; Pan, WJ; Farr, GH; Flynn, C; Yuan, HD; Takada, S; Kimelman, D; Li, L |
| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2001 |
| 卷号 | 7期号:4页码:801-809 |
| 通讯作者 | Li, L (reprint author), Univ Connecticut, Dept Genet & Dev Biol, Farmington, CT 06030 USA.,lil@sunm.shcnc.ac.cn ; dwu@neuron.uchc.edu |
| 英文摘要 | To understand how the Wnt coreceptor LRP-5 is involved in transducing the canonical Wnt signals, we identified Axin as a protein that interacts with the intracellular domain of LRP-5. LRP-5, when expressed in fibroblast cells, showed no effect on the canonical Wnt signaling pathway by itself, but acted synergistically with Wnt. In contrast, LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind Axin and that induce LEF-1 activation by destabilizing Axin and stabilizing beta -catenin. Addition of Wnt caused the translocation of Axin to the membrane and enhanced the interaction between Axin and LRP-5. In addition, the LRP-5 sequences involved in interactions with Axin are required for LEF-1 activation. Thus, we conclude that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | BETA-CATENIN ; NEGATIVE REGULATOR ; WINGLESS ; DROSOPHILA ; XENOPUS ; KINASE ; CANCER ; LEF-1 ; PHOSPHORYLATION ; SPECIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000168462800010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2657]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mao, JH,Wang, JY,Liu, B,et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway[J]. MOLECULAR CELL,2001,7(4):801-809. |
| APA | Mao, JH.,Wang, JY.,Liu, B.,Pan, WJ.,Farr, GH.,...&Wu, DQ.(2001).Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.MOLECULAR CELL,7(4),801-809. |
| MLA | Mao, JH,et al."Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway".MOLECULAR CELL 7.4(2001):801-809. |
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