Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter
文献类型：期刊论文
| 作者 | Liu, ZP; Wang, Y; Zhang, J; Ding, JG; Guo, LH; Cui, DF; Fei, JA |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2001 |
| 卷号 | 12期号:4页码:699-702 |
| 关键词 | dopamine dopamine transporter GABA GABA transporter orphanin FQ striatal synaptosomes |
| 通讯作者 | Fei, JA (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Beijing 100864, Peoples R China., |
| 英文摘要 | Orphanin FQ, also known as nociceptin (NC), is a well-known ligand for opioid receptor-like ORLI receptor. This heptadecapeptide was identified as potently inhibiting the uptake of rat dopamine transporter (rDAT) which is stably expressed in CHO cells (designated D8 cells). Further kinetic analysis proved that this occurs through competitive inhibition with an IC50 of about 1.9 muM. Orphanin FQ also inhibits [H-3]dopamine uptake by rat striatal synaptosomes, which confirmed the effect of orphanin FQ on D8 cells. Orphanin FQ was also found to inhibit GABA transporter type I (GATI) but not the serotonin transporter. These results suggest that orphanin FQ is an endogenous antagonist of dopamine transport and that it affects locomotion and other activities at least partly by inhibiting dopamine transporter and directly affecting dopamine transmission or by inhibiting GABA transporter to indirectly change dopamine transmission. NeuroReport 12:699-702 (C) 2001 Lippincott Williams & Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | OPIOID RECEPTOR FAMILY ; MOLECULAR-CLONING ; CDNA CLONING ; GENE FAMILY ; MEMBER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000167504700016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2658]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, ZP,Wang, Y,Zhang, J,et al. Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter[J]. NEUROREPORT,2001,12(4):699-702. |
| APA | Liu, ZP.,Wang, Y.,Zhang, J.,Ding, JG.,Guo, LH.,...&Fei, JA.(2001).Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter.NEUROREPORT,12(4),699-702. |
| MLA | Liu, ZP,et al."Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter".NEUROREPORT 12.4(2001):699-702. |
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