The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element
文献类型：期刊论文
| 作者 | Xu, WJ; Yan, MD; Lu, LR; Sun, LY; Theze, J; Zheng, ZC; Liu, XY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 289期号:5页码:979-986 |
| 关键词 | IL-2 TNF-beta 130EBS ETS transcription factor p38 MAPK |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | As an important cytokine of the immune system, interleukin-2 (IL-2) can induce the expression of various genes, one of which is the tumor necrosis factor-beta (TNF-beta). However, the induction mechanism of TNF-beta remains to be fully explored. We have previously shown JAK-STAT pathway mediates TNF-beta gene induction upon IL-2 stimulation through an upstream -200GAS element. In this study, we further demonstrated that there is another essential -130EBS element in TNF-beta gene promoter region. Using IL-2-dependent cell line BAF/BO3beta, we found that this -130EBS element can form a specific complex with nuclear protein, which contained a novel ETS transcription factor. Furthermore, using kinase inhibitors, we revealed that p38 MAP kinase is involved in the formation of -130EBS-protein complex and the subsequent transcriptional activation of TNF-beta gene in response to IL-2 stimulation. Taken together, our results suggested that the complicated IL-2 induction of TNF-beta gene expression requires not only the activation of JAK-STAT pathway on the -200GAS element, but also the cooperation of another signal pathway on the -130EBS element. (C) 2001 Elsevier Science. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | KINASE ACTIVATION ; PROTEIN-KINASE ; T-CELLS ; INTERLEUKIN-2 ; RECEPTOR ; PROLIFERATION ; INHIBITOR ; PHOSPHORYLATION ; TRANSDUCTION ; LYMPHOCYTES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000173406500011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2661]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, WJ,Yan, MD,Lu, LR,et al. The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,289(5):979-986. |
| APA | Xu, WJ.,Yan, MD.,Lu, LR.,Sun, LY.,Theze, J.,...&Liu, XY.(2001).The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,289(5),979-986. |
| MLA | Xu, WJ,et al."The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289.5(2001):979-986. |
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