Differential regulation of interleukin-12 and interleukin-10 by heat shock response in murine peritoneal macrophages
文献类型：期刊论文
| 作者 | Wang, XY; Zou, YU; Wang, Y; Li, CL; Chang, ZL |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2001 |
| 卷号 | 287期号:5页码:1041-1044 |
| 关键词 | heat shock response LPS IL-12 IL-10 macrophages |
| 通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | Heat shock response is a conserved stress response and has been shown to have anti-inflammatory effects. We investigated the effect of heat shock response on LPS-induced production of IL-12 and IL-10, which are two important cytokines playing contradictory roles in regulation of immune response, by murine peritoneal macrophages. The data showed that induction of heat shock response strongly suppressed LPS-induced production of IL-12 while augmented that of IL-10, suggesting the pleiotropic effects of heat shock response on immune regulatory gene expression. Also, the novel observation on up-regulation of IL-10 by heat shock response adds to the mechanism by which heat shock response exerts its anti-inflammatory effects. (C) 2001 Academic Press. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | IL-10 GENE-EXPRESSION ; PROTEASOME ; INDUCTION ; CELLS ; SP1 ; P40 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171552200001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2662]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XY,Zou, YU,Wang, Y,et al. Differential regulation of interleukin-12 and interleukin-10 by heat shock response in murine peritoneal macrophages[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2001,287(5):1041-1044. |
| APA | Wang, XY,Zou, YU,Wang, Y,Li, CL,&Chang, ZL.(2001).Differential regulation of interleukin-12 and interleukin-10 by heat shock response in murine peritoneal macrophages.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,287(5),1041-1044. |
| MLA | Wang, XY,et al."Differential regulation of interleukin-12 and interleukin-10 by heat shock response in murine peritoneal macrophages".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 287.5(2001):1041-1044. |
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